Anti-TWF2 Antibody (CAB19898)[KO Validated]

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SKU:
CAB19898
Product type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-TWF2 Antibody [KO Validated]
Antibody SKU:CAB19898
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant protein of human TWF2.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:293T
Immunogen:Recombinant protein of human TWF2.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:11344
Uniprot:Q6IBS0
Cellular Location:Cell projection, Cytoplasm, cytoskeleton, perinuclear region, stereocilium
Calculated MW:39kDa
Observed MW:40KDa
Anti-TWF2 Antibody [KO Validated] (CAB19898)Western blot analysis of extracts from normal (control) and TWF2 knockout (KO) 293T cells, using TWF2 antibody (CAB19898) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
Synonyms:TWF2, A6RP, A6r, MSTP011, PTK9L
Background:The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein.
UniProt Protein Function:A6r: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia. Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: stereocilium; cytoskeleton; growth cone; myofibril; lamellipodium; perinuclear region of cytoplasm; cytoplasm; filopodium

Molecular Function:actin monomer binding; phosphatidylinositol-4,5-bisphosphate binding; protein kinase C binding; ATP binding

Biological Process: cell projection organization and biogenesis; sequestering of actin monomers; negative regulation of actin filament polymerization; regulation of actin cytoskeleton organization and biogenesis; positive regulation of axon extension; regulation of microvillus length; barbed-end actin filament capping

NCBI Summary:The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein. [provided by RefSeq, Jul 2008]
UniProt Code:Q6IBS0
NCBI GenInfo Identifier:94730596
NCBI Gene ID:11344
NCBI Accession:Q6IBS0.2
UniProt Secondary Accession:Q6IBS0,Q9Y3F5,
UniProt Related Accession:Q6IBS0
Molecular Weight:349
NCBI Full Name:Twinfilin-2
NCBI Synonym Full Names:twinfilin actin-binding protein 2
NCBI Official Symbol:TWF2  
NCBI Official Synonym Symbols:A6r; A6RP; PTK9L; MSTP011  
NCBI Protein Information:twinfilin-2; A6-related protein; twinfilin-1-like protein; twinfilin, actin-binding protein, homolog 2; protein tyrosine kinase 9-like (A6-related protein); PTK9L protein tyrosine kinase 9-like (A6-related protein)
UniProt Protein Name:Twinfilin-2
UniProt Synonym Protein Names:A6-related protein; hA6RP; Protein tyrosine kinase 9-like; Twinfilin-1-like protein
Protein Family:Twinfilin
UniProt Gene Name:TWF2  
UniProt Entry Name:TWF2_HUMAN

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