Anti-TSHB Antibody (CAB14523)
- SKU:
- CAB14523
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-TSHB Antibody |
| Antibody SKU: | CAB14523 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human TSHB (NP_000540.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29, LO2, Mouse liver, Mouse kidney, Mouse brain, Rat liver, Rat kidney, Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human TSHB (NP_000540.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YCMT RDIN GKLF LPKY ALSQ DVCT YRDF IYRT VEIP GCPL HVAP YFSY PVAL SCKC GKCN TDYS DCIH EAIK TNYC TKPQ KSYL VGFS V |
| Gene ID: | 7252 |
| Uniprot: | P01222 |
| Cellular Location: | Secreted |
| Calculated MW: | 10kDa/15kDa |
| Observed MW: | 16kDa |
| Synonyms: | TSHB, TSH-B, TSH-BETA |
| Background: | The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. |
| UniProt Protein Function: | TSHB: Indispensable for the control of thyroid structure and metabolism. Belongs to the glycoprotein hormones subunit beta family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 1p13 Cellular Component: extracellular region Molecular Function:hormone activity Biological Process: G-protein coupled receptor protein signaling pathway; anatomical structure morphogenesis; cellular protein metabolic process; cell-cell signaling; response to estrogen stimulus; peptide hormone processing; response to calcium ion; response to vitamin A Disease: Hypothyroidism, Congenital, Nongoitrous, 4 |
| NCBI Summary: | The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013] |
| UniProt Code: | P01222 |
| NCBI GenInfo Identifier: | 311033515 |
| NCBI Gene ID: | 7252 |
| NCBI Accession: | P01222.2 |
| UniProt Secondary Accession: | P01222,Q16163, B1AKP0, |
| UniProt Related Accession: | P01222 |
| Molecular Weight: | 138 |
| NCBI Full Name: | Thyrotropin subunit beta |
| NCBI Synonym Full Names: | thyroid stimulating hormone, beta |
| NCBI Official Symbol: | TSHB |
| NCBI Official Synonym Symbols: | TSH-B; TSH-BETA |
| NCBI Protein Information: | thyrotropin subunit beta; thyrotropin beta chain |
| UniProt Protein Name: | Thyrotropin subunit beta |
| UniProt Synonym Protein Names: | Thyroid-stimulating hormone subunit beta; TSH-B; TSH-beta; Thyrotropin beta chain; INN: Thyrotropin alfa |
| Protein Family: | Thyrotropin |
| UniProt Gene Name: | TSHB |
| UniProt Entry Name: | TSHB_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TSHB antibody (CAB14523) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
Related Products
Rat Thyrotropin subunit beta / TSHB ELISA Kit
Chicken Thyrotropin subunit beta (TSHB) ELISA Kit
Rat Thyrotropin subunit beta (Tshb) ELISA Kit
Mouse Thyrotropin subunit beta (Tshb) ELISA Kit
