Anti-TRPM1 Antibody (CAB17509)
- SKU:
- CAB17509
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| Antibody Name: | Anti-TRPM1 Antibody |
| Antibody SKU: | CAB17509 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1343-1642 of human TRPM1 (NP_001238949.1). |
| Application: | IHC |
| Recommended Dilution: | IHC 1:50 - 1:100 |
| Reactivity: | Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1343-1642 of human TRPM1 (NP_001238949.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FRIK EEKD VKTH LVPE CQNS LHLS LGTS TSAT PDGS HLAV DDLK NAEE SKLG PDIG ISKE DDER QTDS KKEE TISP SLNK TDVI HGQD KSDV QNTQ LTVE TTNI EGTI SYPL EETK ITRY FPDE TINA CKTM KSRS FVYS RGRK LVGG VNQD VEYS SITD QQLT TEWQ CQVQ KITR SHST DIPY IVSE AAVQ AEHK EQFA DMQD EHHV AEAI PRIP RLSL TITD RNGM ENLL SVKP DQTL GFPS LRSK SLHG HPRN VKSI QGKL DRSG HASS VSSL VIVS GMTA EEKK VKKE KAST ETEC |
| Gene ID: | 4308 |
| Uniprot: | Q7Z4N2 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
 | Immunohistochemistry - TRPM1 Polyclonal Antibody (CAB17509) |
| Synonyms: | CSNB1C, LTRPC1, MLSN1, TRPM1 |
| Background: | This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011] |
| UniProt Protein Function: | TRPM1: a transient receptor potential (TRP) ion channel. TRP voltage-independent calcium-permeable cation channels are divided into six subfamilies, two of which (TRPC and TRPM) have members that are widely expressed. Its expression is inversely correlated with melanoma aggressiveness, suggesting that it suppresses melanoma metastasis. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Channel, calcium; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 15q13.3 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:calcium channel activity Biological Process: metabotropic glutamate receptor signaling pathway; transport; visual perception Disease: Night Blindness, Congenital Stationary, Type 1c |
| NCBI Summary: | This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q7Z4N2 |
| NCBI GenInfo Identifier: | 34849477 |
| NCBI Gene ID: | 4308 |
| NCBI Accession: | BC058286 |
| UniProt Secondary Accession: | Q7Z4N2,O75560, Q6PE48, Q7Z4N1, Q7Z4N3, Q7Z4N4, Q7Z4N5 D9IDV2, D9IDV3, F8W865, H0YN37, |
| UniProt Related Accession: | Q7Z4N2 |
| Molecular Weight: | 15,099 Da |
| NCBI Full Name: | Homo sapiens transient receptor potential cation channel, subfamily M, member 1, mRNA |
| NCBI Synonym Full Names: | transient receptor potential cation channel subfamily M member 1 |
| NCBI Official Symbol: | TRPM1 |
| NCBI Official Synonym Symbols: | MLSN1; CSNB1C; LTRPC1 |
| NCBI Protein Information: | transient receptor potential cation channel subfamily M member 1 |
| UniProt Protein Name: | Transient receptor potential cation channel subfamily M member 1 |
| UniProt Synonym Protein Names: | Long transient receptor potential channel 1; LTrpC1; Melastatin-1 |
| Protein Family: | Transient receptor potential cation channel subfamily |
| UniProt Gene Name: | TRPM1 |
| UniProt Entry Name: | TRPM1_HUMAN |
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