Anti-TrkB Antibody (CAB2099)

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SKU:
CAB2099
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Developmental Biology
Frequently bought together:

Description

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Antibody Name:Anti-TrkB Antibody
Antibody SKU:CAB2099
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 32-282 of human TrkB (NP_001007098.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:SGC-7901, 293T, SW480, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 32-282 of human TrkB (NP_001007098.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CPTS CKCS ASRI WCSD PSPG IVAF PRLE PNSV DPEN ITEI FIAN QKRL EIIN EDDV EAYV GLRN LTIV DSGL KFVA HKAF LKNS NLQH INFT RNKL TSLS RKHF RHLD LSEL ILVG NPFT CSCD IMWI KTLQ EAKS SPDT QDLY CLNE SSKN IPLA NLQI PNCG LPSA NLAA PNLT VEEG KSIT LSCS VAGD PVPN MYWD VGNL VSKH MNET SHTQ GSLR ITNI SSDD SGKQ ISCV AENL VGED QDSV NLT
Gene ID:4915
Uniprot:Q16620
Cellular Location:Cell membrane, Endosome membrane, Single-pass type I membrane protein
Calculated MW:35kDa/53kDa/59kDa/60kDa/81kDa/91kDa/93kDa
Observed MW:140kDa
Synonyms:NTRK2, GP145-TrkB, TRKB, trk-B, TrkB, OBHD
Background:This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:TrkB: a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described.
UniProt Protein Details:

Protein type:Membrane protein, integral; Kinase, protein; Protein kinase, TK; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; Trk family

Chromosomal Location of Human Ortholog: 9q22.1

Cellular Component: cell surface; rough endoplasmic reticulum; integral to plasma membrane; dendritic spine; terminal button; excitatory synapse; perikaryon; cytosol; postsynaptic membrane; growth cone; presynaptic active zone; endosome membrane; receptor complex

Molecular Function:brain-derived neurotrophic factor receptor activity; neurotrophin binding; protein homodimerization activity; ephrin receptor binding; brain-derived neurotrophic factor binding; ATP binding

Biological Process: circadian rhythm; mechanoreceptor differentiation; peptidyl-tyrosine phosphorylation; retinal rod cell development; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; neuron migration; regulation of dendrite development; regulation of neurotransmitter secretion; positive regulation of synaptic transmission, glutamatergic; neuron differentiation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; oligodendrocyte differentiation; feeding behavior; negative regulation of neuron apoptosis; inflammatory response; vasculogenesis; neuromuscular junction development; central nervous system neuron development; aging; response to light stimulus; brain-derived neurotrophic factor receptor signaling pathway; adenylate cyclase activation; regulation of protein kinase B signaling cascade; learning; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; peripheral nervous system neuron development; long-term memory; glutamate secretion; positive regulation of axonogenesis; cerebral cortex development; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Obesity, Hyperphagia, And Developmental Delay

NCBI Summary:This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
UniProt Code:Q16620
NCBI GenInfo Identifier:2497560
NCBI Gene ID:4915
NCBI Accession:Q16620.1
UniProt Secondary Accession:Q16620,Q16675, Q59GJ1, Q8WXJ5, Q8WXJ6, Q8WXJ7, B1ANZ4 B4DFV9,
UniProt Related Accession:Q16620
Molecular Weight:822
NCBI Full Name:BDNF/NT-3 growth factors receptor
NCBI Synonym Full Names:neurotrophic tyrosine kinase, receptor, type 2
NCBI Official Symbol:NTRK2  
NCBI Official Synonym Symbols:TRKB; trk-B; GP145-TrkB  
NCBI Protein Information:BDNF/NT-3 growth factors receptor; tyrosine kinase receptor B; tropomyosin-related kinase B; BDNF-tropomyosine receptor kinase B
UniProt Protein Name:BDNF/NT-3 growth factors receptor
UniProt Synonym Protein Names:GP145-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase B
Protein Family:BDNF/NT-3 growth factors receptor
UniProt Gene Name:NTRK2  
UniProt Entry Name:NTRK2_HUMAN
Anti-TrkB Antibody (CAB2099)Western blot analysis of extracts of various cell lines, using TrkB antibody (CAB2099) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.

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