Anti-TRIOBP Antibody (CAB4485)
- SKU:
- CAB4485
- Product type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- TRIOBP
- DFNB28
- HRIHFB2122
- TAP68
- TARA
- dJ37E16.4
Frequently bought together:
Description
| Product Name: | TRIOBP Rabbit pAb |
| Product Code: | CAB4485 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | TRIOBP, DFNB28, HRIHFB2122, TAP68, TARA, dJ37E16.4 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-310 of human TRIOBP (NP_008963.3). |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | BxPC-3, U-87MG, HeLa, LO2, A-549, SW620, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-310 of human TRIOBP (NP_008963.3). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DVTK LSDS NKEN ALHS YSTQ KGPL KAGE QRAG SEVI SRGG PRKA DGQR QALD YVEL SPLT QASP QRAR TPAR TPDR LAKQ EELE RDLA QRSE ERRK WFEA TDSR TPEV PAGE GPRR GLGA PLTE DQQN RLS |
| Gene ID: | 11078 |
| Uniprot: | Q9H2D6 |
| Cellular Location: | Cytoplasm, Midbody, Nucleus, centrosome, cytoskeleton, cytoskeleton, microtubule organizing center |
| Calculated MW: | 47kDa/68kDa/74kDa/125kDa/243kDa/250kDa/261kDa |
| Observed MW: | 70kDa |
| UniProt Protein Function: | Tara: May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover. Defects in TRIOBP are the cause of deafness autosomal recessive type 28 (DFNB28). 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Actin-binding; Cytoskeletal Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: focal adhesion; cytoplasm; microtubule organizing center; midbody; nucleus; actin cytoskeleton Molecular Function:actin filament binding; ubiquitin protein ligase binding; GTP-Rho binding; myosin II binding Biological Process: mitosis; actin modification; cell division; barbed-end actin filament capping Disease: Deafness, Autosomal Recessive 28 |
| NCBI Summary: | This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008] |
| UniProt Code: | Q9H2D6 |
| NCBI GenInfo Identifier: | 90110075 |
| NCBI Gene ID: | 11078 |
| NCBI Accession: | Q9H2D6.3 |
| UniProt Secondary Accession: | Q9H2D6,O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1 Q9BT77, B1AHD4, B1AHD7, F2Z2W0, F8W6V6, |
| UniProt Related Accession: | Q9H2D6 |
| Molecular Weight: | 2365 |
| NCBI Full Name: | TRIO and F-actin-binding protein |
| NCBI Synonym Full Names: | TRIO and F-actin binding protein |
| NCBI Official Symbol: | TRIOBP |
| NCBI Official Synonym Symbols: | TARA; TAP68; DFNB28; dJ37E16.4; HRIHFB2122 |
| NCBI Protein Information: | TRIO and F-actin-binding protein; protein Tara; tara-like protein; trio-associated repeat on actin |
| UniProt Protein Name: | TRIO and F-actin-binding protein |
| UniProt Synonym Protein Names: | Protein Tara; Trio-associated repeat on actin |
| Protein Family: | TRIO and F-actin-binding protein |
| UniProt Gene Name: | TRIOBP |
| UniProt Entry Name: | TARA_HUMAN |
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