Anti-TRIM37 Antibody (CAB18307)
- SKU:
- CAB18307
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| Antibody Name: | Anti-TRIM37 Antibody |
| Antibody SKU: | CAB18307 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human TRIM37. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse testis, Mouse pancreas, Rat testis |
| Immunogen: | Recombinant protein of human TRIM37. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4591 |
| Uniprot: | O94972 |
| Cellular Location: | |
| Calculated MW: | 108kDa |
| Observed MW: | 135kDa |
 | Western blot - TRIM37 Polyclonal Antibody (CAB18307) |
| Synonyms: | MUL, POB1, TEF3, TRIM37 |
| Background: | This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. |
| UniProt Protein Function: | TRIM37: E3 ubiquitin-protein ligase. Defects in TRIM37 are the cause of mulibrey nanism (MUL); also known as muscle-liver-brain-eye nanism. MUL is an autosomal recessive disorder that involves several tissues of mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia of various endocrine glands causing hormonal deficiency are common. Belongs to the TRIM/RBCC family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ligase; Ubiquitin ligase; EC 6.3.2.-; Oncoprotein; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 17q23.2 Cellular Component: cytoplasm; cytosol; ESC/E(Z) complex; peroxisome Molecular Function:protein binding; protein homodimerization activity; tumor necrosis factor receptor binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity Biological Process: activation of NF-kappaB transcription factor; inhibition of NF-kappaB transcription factor; negative regulation of centriole replication; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; protein autoubiquitination Disease: Mulibrey Nanism |
| NCBI Summary: | This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. [provided by RefSeq, Mar 2016] |
| UniProt Code: | O94972 |
| NCBI GenInfo Identifier: | 55976224 |
| NCBI Gene ID: | 4591 |
| NCBI Accession: | O94972.2 |
| UniProt Secondary Accession: | O94972,Q7Z3E6, Q8IYF7, Q8WYF7, A8K0V9, A8K8U4, A8MZ79 B4DGZ3, F8WEE6, |
| UniProt Related Accession: | O94972 |
| Molecular Weight: | 103,941 Da |
| NCBI Full Name: | E3 ubiquitin-protein ligase TRIM37 |
| NCBI Synonym Full Names: | tripartite motif containing 37 |
| NCBI Official Symbol: | TRIM37 |
| NCBI Official Synonym Symbols: | MUL; POB1; TEF3 |
| NCBI Protein Information: | E3 ubiquitin-protein ligase TRIM37 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase TRIM37 |
| UniProt Synonym Protein Names: | Mulibrey nanism protein |
| UniProt Gene Name: | TRIM37 |
| UniProt Entry Name: | TRI37_HUMAN |
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