Anti-TREH Antibody (CAB15397)

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SKU:
CAB15397
Product type:
Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
Frequently bought together:

Description

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Antibody Name:Anti-TREH Antibody
Antibody SKU:CAB15397
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 350-556 of human TREH (NP_009111.2).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 350-556 of human TREH (NP_009111.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:NAFL CQAE ELMS NFYS RLGN DSQA TKYR ILRS QRLA ALNT VLWD EQTG AWFD YDLE KKKK NREF YPSN LTPL WAGC FSDP GVAD KALK YLED NRIL TYQY GIPT SLQK TGQQ WDFP NAWA PLQD LVIR GLAK APLR RAQE VAFQ LAQN WIRT NFDV YSQK SAMY EKYD VSNG GQPG GGGE YEVQ EGFG WTNG VVLM LLDR YGDR LTS
Gene ID:11181
Uniprot:O43280
Cellular Location:Cell membrane, GPI-anchor, Lipid-anchor
Calculated MW:62kDa/66kDa
Observed MW:Refer to figures
Synonyms:TREH, TRE, TREA, trehalase
Background:This gene encodes an enzyme that hydrolyses trehalose, a disaccharide formed from two glucose molecules found mainly in fungi, plants, and insects. A partial duplication of this gene is located adjacent to this locus on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:TREH: Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose. Deficiency of TREH results in isolated trehalose intolerance that causes gastrointestinal symptoms after ingestion of edible mushrooms. Belongs to the glycosyl hydrolase 37 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.2.1.28; Membrane protein, GPI anchor; Carbohydrate Metabolism - starch and sucrose; Hydrolase

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: anchored to plasma membrane; plasma membrane

Molecular Function:alpha,alpha-trehalase activity

Biological Process: polysaccharide digestion; organ morphogenesis; trehalose catabolic process; trehalose metabolic process; carbohydrate metabolic process; pathogenesis

Disease: Trehalase Deficiency

NCBI Summary:This gene encodes an enzyme that hydrolyses trehalose, a disaccharide formed from two glucose molecules found mainly in fungi, plants, and insects. A partial duplication of this gene is located adjacent to this locus on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
UniProt Code:O43280
NCBI GenInfo Identifier:116284412
NCBI Gene ID:11181
NCBI Accession:NP_009111.2
UniProt Secondary Accession:O43280,Q32MB9, Q53FY8,
UniProt Related Accession:O43280
Molecular Weight:62,941 Da
NCBI Full Name:trehalase isoform 1
NCBI Synonym Full Names:trehalase (brush-border membrane glycoprotein)
NCBI Official Symbol:TREH  
NCBI Official Synonym Symbols:TRE; TREA  
NCBI Protein Information:trehalase; alpha,alpha-trehalose glucohydrolase
UniProt Protein Name:Trehalase
UniProt Synonym Protein Names:Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase
Protein Family:Trehalase
UniProt Gene Name:TREH  
UniProt Entry Name:TREA_HUMAN

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