Anti-TRAF7 Antibody (CAB3095)
- SKU:
- CAB3095
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-TRAF7 Antibody |
| Antibody SKU: | CAB3095 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human TRAF7 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse fetal stomach |
| Immunogen: | A synthetic peptide of human TRAF7 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 84231 |
| Uniprot: | Q6Q0C0 |
| Cellular Location: | Cytoplasmic vesicle |
| Calculated MW: | 66kDa/74kDa |
| Observed MW: | 70kDa |
| Synonyms: | TRAF7, RFWD1, RNF119 |
| Background: |
| UniProt Protein Function: | TRAF7: E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. Belongs to the WD repeat TRAF7 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system; EC 6.3.2.-; Ubiquitin ligase; EC 6.3.2.19; Ligase Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: intracellular membrane-bound organelle; perinuclear region of cytoplasm; cytoplasmic membrane-bound vesicle; plasma membrane; nucleus; cytosol; ubiquitin ligase complex Molecular Function:protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity Biological Process: positive regulation of protein sumoylation; regulation of protein localization; positive regulation of MAPKKK cascade; transcription, DNA-dependent; apoptosis; activation of MAPKKK activity; protein ubiquitination; negative regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004] |
| UniProt Code: | Q6Q0C0 |
| NCBI GenInfo Identifier: | 54036486 |
| NCBI Gene ID: | 84231 |
| NCBI Accession: | Q6Q0C0.1 |
| UniProt Secondary Accession: | Q6Q0C0,Q9H073, |
| UniProt Related Accession: | Q6Q0C0 |
| Molecular Weight: | 670 |
| NCBI Full Name: | E3 ubiquitin-protein ligase TRAF7 |
| NCBI Synonym Full Names: | TNF receptor-associated factor 7, E3 ubiquitin protein ligase |
| NCBI Official Symbol: | TRAF7 |
| NCBI Official Synonym Symbols: | RFWD1; RNF119 |
| NCBI Protein Information: | E3 ubiquitin-protein ligase TRAF7; RING finger protein 119; ring finger and WD repeat domain 1; RING finger and WD repeat-containing protein 1 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase TRAF7 |
| UniProt Synonym Protein Names: | RING finger and WD repeat-containing protein 1; RING finger protein 119; TNF receptor-associated factor 7 |
| Protein Family: | E3 ubiquitin-protein ligase |
| UniProt Gene Name: | TRAF7 |
| UniProt Entry Name: | TRAF7_HUMAN |
 | Western blot analysis of extracts of mouse fetal stomach, using TRAF7 antibody (CAB3095). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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