Anti-TRAF7 Antibody (CAB15912)
- SKU:
- CAB15912
- Product type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-TRAF7 Antibody |
| Antibody SKU: | CAB15912 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 260-400 of human TRAF7 (NP_115647.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: | Rat testis, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 260-400 of human TRAF7 (NP_115647.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PHSK YGCT FIGN QDTY ETHL ETCR FEGL KEFL QQTD DRFH EMHV ALAQ KDQE IAFL RSML GKLS EKID QLEK SLEL KFDV LDEN QSKL SEDL MEFR RDAS MLND ELSH INAR LNMG ILGS YDPQ QIFK CKGT FVGH QGPV W |
| Gene ID: | 84231 |
| Uniprot: | Q6Q0C0 |
| Cellular Location: | Cytoplasmic vesicle |
| Calculated MW: | 66kDa/74kDa |
| Observed MW: | 75kDa |
| Synonyms: | TRAF7, RFWD1, RNF119 |
| Background: | Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding. |
| UniProt Protein Function: | TRAF7: E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. Belongs to the WD repeat TRAF7 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system; EC 6.3.2.-; Ubiquitin ligase; EC 6.3.2.19; Ligase Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: intracellular membrane-bound organelle; perinuclear region of cytoplasm; cytoplasmic membrane-bound vesicle; plasma membrane; nucleus; cytosol; ubiquitin ligase complex Molecular Function:protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity Biological Process: positive regulation of protein sumoylation; regulation of protein localization; positive regulation of MAPKKK cascade; transcription, DNA-dependent; apoptosis; activation of MAPKKK activity; protein ubiquitination; negative regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004] |
| UniProt Code: | Q6Q0C0 |
| NCBI GenInfo Identifier: | 54036486 |
| NCBI Gene ID: | 84231 |
| NCBI Accession: | Q6Q0C0.1 |
| UniProt Secondary Accession: | Q6Q0C0,Q9H073, |
| UniProt Related Accession: | Q6Q0C0 |
| Molecular Weight: | 670 |
| NCBI Full Name: | E3 ubiquitin-protein ligase TRAF7 |
| NCBI Synonym Full Names: | TNF receptor-associated factor 7, E3 ubiquitin protein ligase |
| NCBI Official Symbol: | TRAF7 |
| NCBI Official Synonym Symbols: | RFWD1; RNF119 |
| NCBI Protein Information: | E3 ubiquitin-protein ligase TRAF7; RING finger protein 119; ring finger and WD repeat domain 1; RING finger and WD repeat-containing protein 1 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase TRAF7 |
| UniProt Synonym Protein Names: | RING finger and WD repeat-containing protein 1; RING finger protein 119; TNF receptor-associated factor 7 |
| Protein Family: | E3 ubiquitin-protein ligase |
| UniProt Gene Name: | TRAF7 |
| UniProt Entry Name: | TRAF7_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TRAF7 antibody (CAB15912) at 1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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