Anti-TP53BP2 항체 (CAB5704)

Antibody Name:	Anti-TP53BP2 Antibody
Antibody SKU:	CAB5704
Antibody Size:	20uL, 50uL, 100uL
Application:	IHC IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 360-600 of human TP53BP2 (NP_001026855.2).

Application:	IHC IF
Recommended Dilution:	IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 360-600 of human TP53BP2 (NP_001026855.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	STMP RMPS RPEL LVKP ALPD GSLV IQAS EGPM KIQT LPNM RSGA ASQT KGSK IHPV GPDW SPSN ADLF PSQG SASV PQST GNAL DQVD DGEV PLRE KEKK VRPF SMFD AVDQ SNAP PSFG TLRK NQSS EDIL RDAQ VANK NVAK VPPP VPTK PKQI NLPY FGQT NQPP SDIK PDGS SQQL STVV PSMG TKPK PAGQ QPRV LLSP SIPS VGQD QTLS PGSK QESP PAAA VRPF TPQP SKDT L
Gene ID:	7159
Uniprot:	Q13625
Cellular Location:	Cytoplasm, Nucleus, perinuclear region
Calculated MW:	111kDa/125kDa/126kDa
Observed MW:

Synonyms:

TP53BP2, 53BP2, ASPP2, BBP, P53BP2, PPP1R13A

Background:

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene.

UniProt Protein Function:	53BP2: Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. Belongs to the ASPP family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 1q41 Cellular Component: cytoplasm; nucleoplasm; nucleus; perinuclear region of cytoplasm Molecular Function:identical protein binding; NF-kappaB binding; p53 binding; protein binding; SH3/SH2 adaptor activity Biological Process: negative regulation of cell cycle; regulation of apoptosis; signal transduction
NCBI Summary:	This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:	Q13625
NCBI GenInfo Identifier:	33860140
NCBI Gene ID:	7159
NCBI Accession:	Q13625.2
UniProt Secondary Accession:	Q13625,Q12892, Q86X75, Q96KQ3, B4DG66,
UniProt Related Accession:	Q13625
Molecular Weight:	126,323 Da
NCBI Full Name:	Apoptosis-stimulating of p53 protein 2
NCBI Synonym Full Names:	tumor protein p53 binding protein 2
NCBI Official Symbol:	TP53BP2
NCBI Official Synonym Symbols:	BBP; 53BP2; ASPP2; P53BP2; PPP1R13A
NCBI Protein Information:	apoptosis-stimulating of p53 protein 2
UniProt Protein Name:	Apoptosis-stimulating of p53 protein 2
UniProt Synonym Protein Names:	Bcl2-binding protein; Bbp; Renal carcinoma antigen NY-REN-51; Tumor suppressor p53-binding protein 2; 53BP2; p53-binding protein 2; p53BP2
Protein Family:	Apoptosis-stimulating of p53 protein
UniProt Gene Name:	TP53BP2
UniProt Entry Name:	ASPP2_HUMAN

	Immunohistochemistry of paraffin-embedded rat brain using TP53BP2 antibody (CAB5704) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human gastric cancer using TP53BP2 antibody (CAB5704) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse brain using TP53BP2 antibody (CAB5704) at dilution of 1:100 (40x lens).
	Immunofluorescence analysis of A549 cells using TP53BP2 antibody (CAB5704). Blue: DAPI for nuclear staining.

Antibodies

Anti-TP53BP2 Antibody (CAB15105)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)