Anti-TP53BP2 Antibody (CAB15105)
- SKU:
- CAB15105
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-TP53BP2 Antibody |
| Antibody SKU: | CAB15105 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-300 of human TP53BP2 (NP_001026855.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | DU145, OVCAR3, K562, A-549 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-300 of human TP53BP2 (NP_001026855.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RALK GHVE QKRL SNGK LVEE IEQM NNLF QQKQ RELV LAVS KVEE LTRQ LEML KNGR IDSH HDNQ SAVA ELDR LYKE LQLR NKLN QEQN AKLQ QQRE CLNK R |
| Gene ID: | 7159 |
| Uniprot: | Q13625 |
| Cellular Location: | Cytoplasm, Nucleus, perinuclear region |
| Calculated MW: | 111kDa/125kDa/126kDa |
| Observed MW: | 170kDa |
| Synonyms: | TP53BP2, 53BP2, ASPP2, BBP, P53BP2, PPP1R13A |
| Background: | This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | 53BP2: Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. Belongs to the ASPP family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 1q41 Cellular Component: cytoplasm; nucleoplasm; nucleus; perinuclear region of cytoplasm Molecular Function:identical protein binding; NF-kappaB binding; p53 binding; protein binding; SH3/SH2 adaptor activity Biological Process: negative regulation of cell cycle; regulation of apoptosis; signal transduction |
| NCBI Summary: | This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13625 |
| NCBI GenInfo Identifier: | 33860140 |
| NCBI Gene ID: | 7159 |
| NCBI Accession: | Q13625.2 |
| UniProt Secondary Accession: | Q13625,Q12892, Q86X75, Q96KQ3, B4DG66, |
| UniProt Related Accession: | Q13625 |
| Molecular Weight: | 126,323 Da |
| NCBI Full Name: | Apoptosis-stimulating of p53 protein 2 |
| NCBI Synonym Full Names: | tumor protein p53 binding protein 2 |
| NCBI Official Symbol: | TP53BP2 |
| NCBI Official Synonym Symbols: | BBP; 53BP2; ASPP2; P53BP2; PPP1R13A |
| NCBI Protein Information: | apoptosis-stimulating of p53 protein 2 |
| UniProt Protein Name: | Apoptosis-stimulating of p53 protein 2 |
| UniProt Synonym Protein Names: | Bcl2-binding protein; Bbp; Renal carcinoma antigen NY-REN-51; Tumor suppressor p53-binding protein 2; 53BP2; p53-binding protein 2; p53BP2 |
| Protein Family: | Apoptosis-stimulating of p53 protein |
| UniProt Gene Name: | TP53BP2 |
| UniProt Entry Name: | ASPP2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TP53BP2 antibody (CAB15105) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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