Anti-TNR Antibody (CAB15324)
- SKU:
- CAB15324
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-TNR Antibody |
| Antibody SKU: | CAB15324 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1059-1358 of human TNR (NP_003276.3). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:200 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1059-1358 of human TNR (NP_003276.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ISWQ PPRA EIEN YVLT YKST DGSR KELI VDAE DTWI RLEG LLEN TDYT VLLQ AAQD TTWS SITS TAFT TGGR VFPH PQDC AQHL MNGD TLSG VYPI FLNG ELSQ KLQV YCDM TTDG GGWI VFQR RQNG QTDF FRKW ADYR VGFG NVED EFWL GLDN IHRI TSQG RYEL RVDM RDGQ EAAF ASYD RFSV EDSR NLYK LRIG SYNG TAGD SLSY HQGR PFST EDRD NDVA VTNC AMSY KGAW WYKN CHRT NLNG KYGE SRHS QGIN WYHW KGHE FSIP FVEM KMRP YNHR LMAG RKRQ SLQF |
| Gene ID: | 7143 |
| Uniprot: | Q92752 |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
| Calculated MW: | 139kDa/149kDa |
| Observed MW: | 149kDa |
| Synonyms: | TNR, TN-R |
| Background: | This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The encoded protein is restricted to the central nervous system. The protein may play a role in neurite outgrowth, neural cell adhesion and modulation of sodium channel function. It is a constituent of perineuronal nets. |
| UniProt Protein Function: | TNR: Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance. Belongs to the tenascin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1q24 Cellular Component: nucleoplasm; proteinaceous extracellular matrix; cell surface; cytoplasm; extracellular region; nucleus; lipid raft Biological Process: negative regulation of axon extension involved in regeneration; axon guidance; extracellular matrix organization and biogenesis; synapse organization and biogenesis; neuron adhesion; negative regulation of cell-cell adhesion; cell adhesion; neuromuscular process controlling balance; positive regulation of synaptic transmission, glutamatergic; negative regulation of synaptic transmission; associative learning; telencephalon cell migration; positive regulation of transmission of nerve impulse |
| NCBI Summary: | This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The encoded protein is restricted to the central nervous system. The protein may play a role in neurite outgrowth, neural cell adhesion and modulation of sodium channel function. It is a constituent of perineuronal nets. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q92752 |
| NCBI GenInfo Identifier: | 311033534 |
| NCBI Gene ID: | 7143 |
| NCBI Accession: | Q92752.3 |
| UniProt Secondary Accession: | Q92752,Q15568, Q5R3G0, C9J563, |
| UniProt Related Accession: | Q92752 |
| Molecular Weight: | |
| NCBI Full Name: | Tenascin-R |
| NCBI Synonym Full Names: | tenascin R |
| NCBI Official Symbol: | TNR |
| NCBI Official Synonym Symbols: | TN-R |
| NCBI Protein Information: | tenascin-R; janusin; restrictin |
| UniProt Protein Name: | Tenascin-R |
| UniProt Synonym Protein Names: | Janusin; Restrictin |
| Protein Family: | Tenascin |
| UniProt Gene Name: | TNR |
| UniProt Entry Name: | TENR_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TNR antibody (CAB15324) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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