Anti-TNIP2 Antibody (CAB4962)

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SKU:
CAB4962
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
TNIP2
ABIN2
FLIP1
KLIP
Frequently bought together:

Description

Product Name:TNIP2 Rabbit pAb
Product Code:CAB4962
Size:20uL, 50uL, 100uL
Synonyms:TNIP2, ABIN2, FLIP1, KLIP
Applications:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 240-429 of human TNIP2 (NP_077285.3).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse pancreas
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 240-429 of human TNIP2 (NP_077285.3).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GLHA QLRG LQIP HEPE LMRK EISR LNRQ LEEK INDC AEVK QELA ASRT ARDA ALER VQML EQQI LAYK DDFM SERA DRER AQSR IQEL EEKV ASLL HQVS WRQD SREP DAGR IHAG SKTA KYLA ADAL ELMV PGGW RPGT GSQQ PEPP AEGG HPGA AQRG QGDL QCPH CLQC FSDE QGEE LLRH VAEC CQ
Gene ID:79155
Uniprot:Q8NFZ5
Cellular Location:Cytoplasm, Nucleus
Calculated MW:36kDa/48kDa
Observed MW:49kDa
UniProt Protein Function:TNIP2: Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function:polyubiquitin binding; protein binding; protein kinase binding

Biological Process: positive regulation of B cell activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of macrophage activation; positive regulation of transcription from RNA polymerase II promoter; protein stabilization; stress-activated MAPK cascade; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 9 signaling pathway

NCBI Summary:This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014]
UniProt Code:Q8NFZ5
NCBI GenInfo Identifier:74715616
NCBI Gene ID:79155
NCBI Accession:Q8NFZ5.1
UniProt Secondary Accession:Q8NFZ5,Q7L5L2, Q9BQR6, Q9H682, B1AKS4, B3KTY8, D3DVQ9
UniProt Related Accession:Q8NFZ5
Molecular Weight:36,682 Da
NCBI Full Name:TNFAIP3-interacting protein 2
NCBI Synonym Full Names:TNFAIP3 interacting protein 2
NCBI Official Symbol:TNIP2  
NCBI Official Synonym Symbols:KLIP; ABIN2; FLIP1  
NCBI Protein Information:TNFAIP3-interacting protein 2
UniProt Protein Name:TNFAIP3-interacting protein 2
UniProt Synonym Protein Names:A20-binding inhibitor of NF-kappa-B activation 2; ABIN-2; Fetal liver LKB1-interacting protein
Protein Family:TNFAIP3-interacting protein
UniProt Gene Name:TNIP2  
UniProt Entry Name:TNIP2_HUMAN

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