Anti-TNFRSF10B Antibody (CAB1236)
- SKU:
- CAB1236
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-TNFRSF10B Antibody |
| Antibody SKU: | CAB1236 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 56-210 of human TNFRSF10B (NP_003833.4). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | Jurkat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 56-210 of human TNFRSF10B (NP_003833.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ITQQ DLAP QQRA APQQ KRSS PSEG LCPP GHHI SEDG RDCI SCKY GQDY STHW NDLL FCLR CTRC DSGE VELS PCTT TRNT VCQC EEGT FREE DSPE MCRK CRTG CPRG MVKV GDCT PWSD IECV HKES GTKH SGEV PAVE ETVT SSPG TPAS PCS |
| Gene ID: | 8795 |
| Uniprot: | O14763 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 12kDa/45kDa/47kDa |
| Observed MW: | 48kDa |
| Synonyms: | CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9, TNFRSF10B |
| Background: | The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. |
| UniProt Protein Function: | TRAIL-R2: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Homotrimer. Can interact with TRADD and RIPK1. Regulated by p53/TP53. Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral Chromosomal Location of Human Ortholog: 8p22-p21 Cellular Component: integral to membrane; plasma membrane Molecular Function:protein binding; TRAIL binding; receptor activity Biological Process: regulation of apoptosis; caspase activation; cell surface receptor linked signal transduction; positive regulation of I-kappaB kinase/NF-kappaB cascade; induction of apoptosis via death domain receptors; apoptosis; activation of NF-kappaB-inducing kinase Disease: Squamous Cell Carcinoma, Head And Neck |
| NCBI Summary: | The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009] |
| UniProt Code: | O14763 |
| NCBI GenInfo Identifier: | 313104032 |
| NCBI Gene ID: | 8795 |
| NCBI Accession: | O14763.2 |
| UniProt Secondary Accession: | O14763,O14720, O15508, O15517, O15531, Q6UXM8, Q7Z360 Q9BVE0, |
| UniProt Related Accession: | O14763 |
| Molecular Weight: | |
| NCBI Full Name: | Tumor necrosis factor receptor superfamily member 10B |
| NCBI Synonym Full Names: | tumor necrosis factor receptor superfamily, member 10b |
| NCBI Official Symbol: | TNFRSF10B |
| NCBI Official Synonym Symbols: | DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5 |
| NCBI Protein Information: | tumor necrosis factor receptor superfamily member 10B; Fas-like protein; death receptor 5; cytotoxic TRAIL receptor-2; TNF receptor superfamily member 10b; apoptosis inducing receptor TRAIL-R2; apoptosis inducing protein TRICK2A/2B; TNF-related apoptosis-inducing ligand receptor 2; death domain containing receptor for TRAIL/Apo-2L; tumor necrosis factor receptor-like protein ZTNFR9; p53-regulated DNA damage-inducible cell death receptor(killer) |
| UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 10B |
| UniProt Synonym Protein Names: | Death receptor 5; TNF-related apoptosis-inducing ligand receptor 2; TRAIL receptor 2; TRAIL-R2; CD_antigen: CD262 |
| UniProt Gene Name: | TNFRSF10B |
| UniProt Entry Name: | TR10B_HUMAN |
 | Western blot analysis of extracts of Jurkat cells, using TNFRSF10B antibody (CAB1236) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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