Anti-TNFRSF10A Antibody (CAB6267)
- SKU:
- CAB6267
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-TNFRSF10A Antibody |
| Antibody SKU: | CAB6267 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 269-468 of human TNFRSF10A (NP_003835.3). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: | DU145 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 269-468 of human TNFRSF10A (NP_003835.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GGDP KCMD RVCF WRLG LLRG PGAE DNAH NEIL SNAD SLST FVSE QQME SQEP ADLT GVTV QSPG EAQC LLGP AEAE GSQR RRLL VPAN GADP TETL MLFF DKFA NIVP FDSW DQLM RQLD LTKN EIDV VRAG TAGP GDAL YAML MKWV NKTG RNAS IHTL LDAL ERME ERHA REKI QDLL VDSG KFIY LEDG TGSA VSLE |
| Gene ID: | 8797 |
| Uniprot: | O00220 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 50kDa |
| Observed MW: | 45kDa |
| Synonyms: | TNFRSF10A, APO2, CD261, DR4, TRAILR-1, TRAILR1 |
| Background: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. |
| UniProt Protein Function: | TRAIL-R1: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 8p21 Cellular Component: plasma membrane; integral to membrane Molecular Function:protein binding; protease binding; death receptor activity; TRAIL binding; receptor activity; transcription factor binding Biological Process: caspase activation; induction of apoptosis via death domain receptors; apoptosis; activation of NF-kappaB-inducing kinase; signal transduction |
| NCBI Summary: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00220 |
| NCBI GenInfo Identifier: | 313104273 |
| NCBI Gene ID: | 8797 |
| NCBI Accession: | O00220.3 |
| UniProt Secondary Accession: | O00220,Q53Y72, Q96E62, A8K5I4, |
| UniProt Related Accession: | O00220 |
| Molecular Weight: | |
| NCBI Full Name: | Tumor necrosis factor receptor superfamily member 10A |
| NCBI Synonym Full Names: | tumor necrosis factor receptor superfamily, member 10a |
| NCBI Official Symbol: | TNFRSF10A |
| NCBI Official Synonym Symbols: | DR4; APO2; CD261; TRAILR1; TRAILR-1 |
| NCBI Protein Information: | tumor necrosis factor receptor superfamily member 10A; TRAIL-R1; TRAIL receptor 1; death receptor 4; cytotoxic TRAIL receptor; TNF-related apoptosis-inducing ligand receptor 1; tumor necrosis factor receptor superfamily member 10a variant 2 |
| UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 10A |
| UniProt Synonym Protein Names: | Death receptor 4; TNF-related apoptosis-inducing ligand receptor 1; TRAIL receptor 1; TRAIL-R1; CD_antigen: CD261 |
| UniProt Gene Name: | TNFRSF10A |
| UniProt Entry Name: | TR10A_HUMAN |
 | Western blot analysis of extracts of DU145 cells, using TNFRSF10A antibody (CAB6267) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded human stomach using TNFRSF10A antibody (CAB6267) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human prostate using TNFRSF10A antibody (CAB6267) at dilution of 1:100 (40x lens). |
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