Anti-TNF Antibody (MACO0517)
- SKU:
- MACO0517
- Product type:
- Antibody
- Reactivity:
- Bovine
- Host Species:
- Mouse
- Isotype:
- IgG2b
- Application:
- ELISA
- Antibody type:
- Monoclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Product Name: | Anti-TNF Antibody |
| Product Sku: | MACO0517 |
| Size: | 50ug |
| Host Species: | Mouse |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Bovine |
| Immunogen: | Recombinant Bovine TNF alpha protein |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%,Protein G purified |
| Clonality: | Monoclonal |
| Isotype: | IgG2b |
| Conjugate: | Non-conjugated |
| Background: | Tumor necrosis factor alpha (TNF?,also known as cachectin and TNFSF1A, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNF? is produced by a wide variety of immune and epithelial cell types. Bovine TNF? consisits of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 178 aa extracellular domain (ECD). Within the ECD, bovine TNF? shares 64%-83% sequence identity with canine, cotton rat, equine, feline, human, mouse, porcine, rat, and rhesus TNF?.The 26 kDa type 2 transmembrane protein is assembled intracellularly to form a noncovalently linked homotrimer. Ligation of this complex induces reverse signaling that promotes lymphocyte costimulation but diminishes monocyte responsiveness. Cleavage of membrane bound TNF? by TACE/ADAM17 releases a 55 kDa soluble trimeric form of TNF?. TNF? trimers bind the ubiquitous TNF RI and the hematopoietic cell restricted TNF RII, both of which are also expressed as homotrimers. TNF? regulates lymphoid tissue development through control of apoptosis. It also promotes inflammatory responses by inducing the activation of vascular endothelial cells and macrophages. TNF? is a key cytokine in several inflammatory disorders. It contributes to the development of type 2 diabetes through its effects on insulin resistance and fatty acid metabolism. |
| Synonyms: | Cachectin,TNF-alpha,Tumor necrosis factor ligand superfamily member 2 |
| UniProt Protein Function: | Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q06599 |
| NCBI GenInfo Identifier: | 150421693 |
| NCBI Gene ID: | 280943 |
| NCBI Accession: | Q06599.2 |
| UniProt Secondary Accession: | Q06599,O18779, Q27978, A4IFT5, A9QWR7 |
| UniProt Related Accession: | Q06599 |
| Molecular Weight: | 25,439 Da |
| NCBI Full Name: | Tumor necrosis factor |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | TNF |
| NCBI Official Synonym Symbols: | TNFa; TNF-a; TNF-alpha |
| NCBI Protein Information: | tumor necrosis factor |
| UniProt Protein Name: | Tumor necrosis factor |
| UniProt Synonym Protein Names: | Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a |
| Protein Family: | |
| UniProt Gene Name: | TNF |
| UniProt Entry Name: | TNFA_BOVIN |
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