Anti-TMPRSS2 Antibody (CAB9126)
- SKU:
- CAB9126
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-TMPRSS2 Antibody |
| Antibody SKU: | CAB9126 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human TMPRSS2 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29, A-549, PC-3, Mouse kidney, Mouse stomach, Rat kidney |
| Immunogen: | A synthesized peptide derived from human TMPRSS2 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7113 |
| Uniprot: | O15393 |
| Cellular Location: | |
| Calculated MW: | 54kDa |
| Observed MW: | 52KDa |
| Synonyms: | PP9284, PRSS10 |
| Background: | This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] |
| UniProt Protein Function: | TMPRSS2: a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] |
| UniProt Protein Details: | Protein type:EC 3.4.21.-; Protease; Membrane protein, integral Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:protein binding; serine-type peptidase activity Biological Process: positive regulation of virion penetration into host cell; protein autoprocessing; proteolysis |
| NCBI Summary: | This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] |
| UniProt Code: | O15393 |
| NCBI GenInfo Identifier: | 115502469 |
| NCBI Gene ID: | 7113 |
| NCBI Accession: | O15393.3 |
| UniProt Secondary Accession: | O15393,Q6GTK7, Q9BXX1, A8K6Z8, B2R8E5, B7Z459, D3DSJ2 F8WES1, |
| UniProt Related Accession: | O15393 |
| Molecular Weight: | 57,690 Da |
| NCBI Full Name: | Transmembrane protease serine 2 |
| NCBI Synonym Full Names: | transmembrane protease, serine 2 |
| NCBI Official Symbol: | TMPRSS2 |
| NCBI Official Synonym Symbols: | PP9284; PRSS10 |
| NCBI Protein Information: | transmembrane protease serine 2 |
| UniProt Protein Name: | Transmembrane protease serine 2 |
| UniProt Synonym Protein Names: | Serine protease 10 |
| Protein Family: | Transmembrane protease serine |
| UniProt Gene Name: | TMPRSS2 |
| UniProt Entry Name: | TMPS2_HUMAN |
 | Western blot - TMPRSS2 Rabbit mAb (CAB9126) |
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