Anti-TMEM59 Antibody (CAB16089)

(No reviews yet) Write a Review
SKU:
CAB16089
Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Autophagy
Frequently bought together:

Description

system_update_alt데이터시트system_update_alt안전 데이터시트
Antibody Name:Anti-TMEM59 Antibody
Antibody SKU:CAB16089
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 36-230 of human TMEM59 (NP_004863.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:U-87MG, A-549
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 36-230 of human TMEM59 (NP_004863.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EAFD SVLG DTAS CHRA CQLT YPLH TYPK EEEL YACQ RGCR LFSI CQFV DDGI DLNR TKLE CESA CTEA YSQS DEQY ACHL GCQN QLPF AELR QEQL MSLM PKMH LLFP LTLV RSFW SDMM DSAQ SFIT SSWT FYLQ ADDG KIVI FQSK PEIQ YAPH LEQE PTNL RESS LSKM SYLQ MRNS QAHR NFLE DGES DGF
Gene ID:9528
Uniprot:Q9BXS4
Cellular Location:Cell membrane, Golgi apparatus membrane, Late endosome membrane, Lysosome membrane, Single-pass type I membrane protein
Calculated MW:36kDa
Observed MW:37KDa
Synonyms:TMEM59, C1orf8, DCF1, HSPC001, PRO195, UNQ169
Background:This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:27273576, PubMed:23376921). Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278). Inhibits APP transport to the cell surface and further shedding (PubMed:20427278).
NCBI Summary:This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
UniProt Code:Q9BXS4
NCBI GenInfo Identifier:758818592
NCBI Gene ID:9528
NCBI Accession:NP_001291972.1
UniProt Secondary Accession:Q9BXS4,O75393, Q4VBP9, Q5T705, Q96KX7, B3KQL7,
UniProt Related Accession:Q9BXS4
Molecular Weight:36,223 Da
NCBI Full Name:transmembrane protein 59 isoform 1
NCBI Synonym Full Names:transmembrane protein 59
NCBI Official Symbol:TMEM59  
NCBI Official Synonym Symbols:DCF1; C1orf8; PRO195; UNQ169; HSPC001  
NCBI Protein Information:transmembrane protein 59
UniProt Protein Name:Transmembrane protein 59
UniProt Synonym Protein Names:Liver membrane-bound protein
Protein Family:Transmembrane protein
UniProt Gene Name:TMEM59  
Anti-TMEM59 Antibody (CAB16089)Western blot analysis of extracts of various cell lines, using TMEM59 antibody (CAB16089) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.

0 Reviews

View AllClose

Related Products