| Background: | The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. |
| UniProt Protein Function: | TIM-3: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9. Belongs to the immunoglobulin superfamily. TIM family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 5q33.3 Cellular Component: integral to membrane Disease: Rheumatoid Arthritis |
| NCBI Summary: | The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q8TDQ0 |
| NCBI GenInfo Identifier: | 311033536 |
| NCBI Gene ID: | 84868 |
| NCBI Accession: | Q8TDQ0.3 |
| UniProt Related Accession: | Q8TDQ0 |
| Molecular Weight: | |
| NCBI Full Name: | Hepatitis A virus cellular receptor 2 |
| NCBI Synonym Full Names: | hepatitis A virus cellular receptor 2 |
| NCBI Official Symbol: | HAVCR2 |
| NCBI Official Synonym Symbols: | TIM3; CD366; KIM-3; SPTCL; TIMD3; Tim-3; TIMD-3; HAVcr-2 |
| NCBI Protein Information: | hepatitis A virus cellular receptor 2 |
| UniProt Protein Name: | Hepatitis A virus cellular receptor 2 |
| UniProt Synonym Protein Names: | T-cell immunoglobulin and mucin domain-containing protein 3; TIMD-3; T-cell immunoglobulin mucin receptor 3; TIM-3; T-cell membrane protein 3 |
| UniProt Gene Name: | HAVCR2 |
| UniProt Entry Name: | HAVR2_HUMAN |
