Anti-THRSP Antibody (CAB7232)
- SKU:
- CAB7232
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-THRSP Antibody |
| Antibody SKU: | CAB7232 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-146 of human THRSP (NP_003242.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain, Mouse liver, Mouse fat, Rat brain, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-146 of human THRSP (NP_003242.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MQVL TKRY PKNC LLTV MDRY AAEV HNME QVVM IPSL LRDV QLSG PGGQ AQAE APDL YTYF TMLK AICV DVDH GLLP REEW QAKV AGSE ENGT AETE EVED ESAS GELD LEAQ FHLH FSSL HHIL MHLT EKAQ EVTR KYQE MTGQ VW |
| Gene ID: | 7069 |
| Uniprot: | Q92748 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 16kDa |
| Observed MW: | 17kDa |
| Synonyms: | THRSP, LPGP1, Lpgp, S14, SPOT14, THRP |
| Background: | The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. |
| UniProt Protein Function: | THRSP: Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA. May function as transcriptional coactivator. May modulate the transcription factor activity of THRB. Belongs to the SPOT14 family. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 11q14.1 Cellular Component: nucleoplasm; cytosol Molecular Function:protein homodimerization activity Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; lipid metabolic process; regulation of lipid biosynthetic process |
| NCBI Summary: | The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92748 |
| NCBI GenInfo Identifier: | 2842710 |
| NCBI Gene ID: | 7069 |
| NCBI Accession: | Q92748.1 |
| UniProt Secondary Accession: | Q92748,B2R4W7, |
| UniProt Related Accession: | Q92748 |
| Molecular Weight: | 146 |
| NCBI Full Name: | Thyroid hormone-inducible hepatic protein |
| NCBI Synonym Full Names: | thyroid hormone responsive |
| NCBI Official Symbol: | THRSP |
| NCBI Official Synonym Symbols: | S14; Lpgp; THRP; LPGP1; SPOT14 |
| NCBI Protein Information: | thyroid hormone-inducible hepatic protein; SPOT14 homolog; spot 14 protein; lipogenic protein 1; thyroid hormone responsive SPOT14; thyroid hormone responsive (SPOT14 homolog, rat) |
| UniProt Protein Name: | Thyroid hormone-inducible hepatic protein |
| UniProt Synonym Protein Names: | Spot 14 protein; S14; SPOT14 |
| Protein Family: | Thyroid hormone-inducible hepatic protein |
| UniProt Gene Name: | THRSP |
| UniProt Entry Name: | THRSP_HUMAN |
 | Western blot analysis of extracts of various cell lines, using THRSP antibody (CAB7232) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 60s. |
 | Immunofluorescence analysis of MCF7 cells using THRSP antibody (CAB7232). Blue: DAPI for nuclear staining. |
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