Anti-Thrombospondin-2 Antibody (CAB8561)
- SKU:
- CAB8561
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-Thrombospondin-2 Antibody |
| Antibody SKU: | CAB8561 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-280 of human THBS2 (NP_003238.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse heart, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-280 of human THBS2 (NP_003238.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HQDK DTTF DLFS ISNI NRKT IGAK QFRG PDPG VPAY RFVR FDYI PPVN ADDL SKIT KIMR QKEG FFLT AQLK QDGK SRGT LLAL EGPG LSQR QFEI VSNG PADT LDLT YWID GTRH VVSL EDVG LADS QWKN VTVQ VAGE TYSL HVGC DLID SFAL DEPF YEHL QAEK SRMY VAKG SARE SHFR GLLQ NVHL VFEN SVED ILSK KGCQ QGQG AEIN AISE NTET LRLG PHVT TEYV GPSS ERRP EVCE RSCE ELGN MVQE L |
| Gene ID: | 7058 |
| Uniprot: | P35442 |
| Cellular Location: | |
| Calculated MW: | 129kDa |
| Observed MW: | 150kDa |
| Synonyms: | THBS2, TSP2 |
| Background: | The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. |
| UniProt Protein Function: | THBS2: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties. Genetic variations in THBS2 may be a cause of susceptibility to intervertebral disk disease (IDD); also known as lumbar disk herniation (LDH). IDD is one of the most common musculo-skeletal disorders and the predominant cause of low-back pain and unilateral leg pain. Belongs to the thrombospondin family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 6q27 Cellular Component: extracellular region; basement membrane Molecular Function:heparin binding; protein binding; calcium ion binding Biological Process: positive regulation of synaptogenesis; negative regulation of angiogenesis; cell adhesion Disease: Intervertebral Disc Disease |
| NCBI Summary: | The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P35442 |
| NCBI GenInfo Identifier: | 215273908 |
| NCBI Gene ID: | 7058 |
| NCBI Accession: | P35442.2 |
| UniProt Secondary Accession: | P35442,Q5RI52, A6H8N1, A7E232, |
| UniProt Related Accession: | P35442 |
| Molecular Weight: | 129,991 Da |
| NCBI Full Name: | Thrombospondin-2 |
| NCBI Synonym Full Names: | thrombospondin 2 |
| NCBI Official Symbol: | THBS2 |
| NCBI Official Synonym Symbols: | TSP2 |
| NCBI Protein Information: | thrombospondin-2 |
| UniProt Protein Name: | Thrombospondin-2 |
| Protein Family: | Thrombospondin |
| UniProt Gene Name: | THBS2 |
| UniProt Entry Name: | TSP2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using THBS2 antibody (CAB8561) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human stomach using THBS2 antibody (CAB8561) at dilution of 1:100 (40x lens). |
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