Anti-THOC6 Antibody (CAB17766)
- SKU:
- CAB17766
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| Antibody Name: | Anti-THOC6 Antibody |
| Antibody SKU: | CAB17766 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of Human THOC6. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Raji, HT-29, LO2, Mouse ovary |
| Immunogen: | A synthetic peptide of Human THOC6. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 79228 |
| Uniprot: | Q86W42 |
| Cellular Location: | |
| Calculated MW: | 32kDa/34kDa/37kDa |
| Observed MW: | 38kDa |
 | Western blot - THOC6 Polyclonal Antibody (CAB17766) |
| Synonyms: | THOC6, WDR58, fSAP35, BBIS |
| Background: | This gene encodes a subunit of the multi-protein THO complex, which is involved in coordination between transcription and mRNA processing. The THO complex is a component of the TREX (transcription/export) complex, which is involved in transcription and export of mRNAs. A missense mutation in this gene is associated with a neurodevelopmental disorder called Beaulieu-Boycott-Innes syndrome. [provided by RefSeq, Dec 2016] |
| UniProt Protein Function: | THOC6: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4. Belongs to the WD repeat THOC6 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA splicing; Spliceosome Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: nuclear chromosome, telomeric region; nucleoplasm; nucleus Biological Process: central nervous system development; intronless viral mRNA export from host nucleus; mRNA 3'-end processing; mRNA export from nucleus; negative regulation of apoptosis; RNA export from nucleus; termination of RNA polymerase II transcription Disease: Beaulieu-boycott-innes Syndrome |
| UniProt Code: | Q86W42 |
| NCBI GenInfo Identifier: | 74759455 |
| NCBI Gene ID: | 79228 |
| NCBI Accession: | Q86W42.1 |
| UniProt Secondary Accession: | Q86W42,Q8NBR1, Q9BTV9, B2RA85, |
| UniProt Related Accession: | Q86W42 |
| Molecular Weight: | 32,891 Da |
| NCBI Full Name: | THO complex subunit 6 homolog |
| NCBI Synonym Full Names: | THO complex 6 |
| NCBI Official Symbol: | THOC6 |
| NCBI Official Synonym Symbols: | BBIS; WDR58; fSAP35 |
| NCBI Protein Information: | THO complex subunit 6 homolog |
| UniProt Protein Name: | THO complex subunit 6 homolog |
| UniProt Synonym Protein Names: | Functional spliceosome-associated protein 35; fSAP35; WD repeat-containing protein 58 |
| Protein Family: | THO complex |
| UniProt Gene Name: | THOC6 |
| UniProt Entry Name: | THOC6_HUMAN |
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