Anti-THOC1 Antibody (CAB8179)
- SKU:
- CAB8179
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | THOC1 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8179 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 428-657 of human THOC1 (NP_005122.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BT-474, MCF7, A-549, HeLa, HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 428-657 of human THOC1 (NP_005122.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TKKI LMGN EELT RLWN LCPD NMEA CKSE TREH MPTL EEFF EEAI EQAD PENM VENE YKAV NNSN YGWR ALRL LARR SPHF FQPT NQQF KSLP EYLE NMVI KLAK ELPP PSEE IKTG EDED EEDN DALL KENE SPDV RRDK PVTG EQIE VFAN KLGE QWKI LAPY LEMK DSEI RQIE CDSE DMKM RAKQ LLVA WQDQ EGVH ATPE NLIN ALNK SGLS DLAE SLTN DNET NS |
| Gene ID: | 9984 |
| Uniprot: | Q96FV9 |
| Cellular Location: | Cytoplasm, Cytoplasm, Nucleus, Nucleus matrix, Nucleus speckle, nucleoplasm |
| Calculated MW: | 43kDa/75kDa |
| Observed MW: | 92kDa |
| Synonyms: | THOC1, HPR1, P84, P84N5 |
| Background: |
| UniProt Protein Function: | Tho1: a protein associated the nuclear matrix. Part of the TREX (transcription/export) complex. The TREX complex is recruited to transcribed genes and travels with the RNA polymerase during elongation. It may physically link proteins that function in transcription and in RNA export. |
| UniProt Protein Details: | Protein type:Spliceosome Chromosomal Location of Human Ortholog: 18p11.32 Cellular Component: cytoplasm; intercellular bridge; nuclear chromosome, telomeric region; nucleoplasm; nucleus Molecular Function:protein binding Biological Process: apoptosis; intronless viral mRNA export from host nucleus; mRNA 3'-end processing; mRNA export from nucleus; negative regulation of isotype switching to IgA isotypes; positive regulation of RNA elongation; regulation of DNA recombination; regulation of RNA elongation; replication fork processing; RNA export from nucleus; RNA processing; termination of RNA polymerase II transcription |
| NCBI Summary: | HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).[supplied by OMIM, Nov 2010] |
| UniProt Code: | Q96FV9 |
| NCBI GenInfo Identifier: | 37999906 |
| NCBI Gene ID: | 9984 |
| NCBI Accession: | Q96FV9.1 |
| UniProt Secondary Accession: | Q96FV9,Q15219, Q64I72, Q64I73, B2RBP6, |
| UniProt Related Accession: | Q96FV9 |
| Molecular Weight: | 43,359 Da |
| NCBI Full Name: | THO complex subunit 1 |
| NCBI Synonym Full Names: | THO complex 1 |
| NCBI Official Symbol: | THOC1 |
| NCBI Official Synonym Symbols: | P84; HPR1; P84N5 |
| NCBI Protein Information: | THO complex subunit 1 |
| UniProt Protein Name: | THO complex subunit 1 |
| UniProt Synonym Protein Names: | Nuclear matrix protein p84; p84N5; hTREX84 |
| UniProt Gene Name: | THOC1 |
| UniProt Entry Name: | THOC1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using THOC1 antibody (CAB8179) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded mouse kidney using THOC1 antibody (CAB8179) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat kidney using THOC1 antibody (CAB8179) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human lung cancer using THOC1 antibody (CAB8179) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using THOC1 antibody (CAB8179) at dilution of 1:100 (40x lens). |
Related Products
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
Human Anti-DSG3 antibody(anti-Desmoglein-3 antibody) ELISA Kit
Anti-CHD1L Antibody (CAB17558)
