Anti-THAP12 Antibody (CAB15085)
- SKU:
- CAB15085
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-THAP12 Antibody |
| Antibody SKU: | CAB15085 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human THAP12 (NP_004696.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, mouse brain, rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human THAP12 (NP_004696.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MPNF CAAP NCTR KSTQ SDLA FFRF PRDP ARCQ KWVE NCRR ADLE DKTP DQLN KHYR LCAK HFET SMIC RTSP YRTV LRDN AIPT IFDL TSHL NNPH SRHR KRIK ELSE DEIR TLKQ KKID ETSE QEQK HKET NNSN AQNP SEEE GEGQ DEDI LPLT LEEK ENKE YLKS LFEI LILM GKQN IPLD GHEA DEIP EGLF TPDN FQAL LECR INSG EEVL RKRF ETTA VNTL FCSK TQQR QMLE ICES CIRE ETLR EVRD SHFF SIIT DDVV DIAG EEHL PVLV RFVD ESHN LREE FIGF LPYE |
| Gene ID: | 5612 |
| Uniprot: | O43422 |
| Cellular Location: | |
| Calculated MW: | 56kDa/87kDa |
| Observed MW: | 52kDa |
| Synonyms: | THAP12, DAP4, P52rIPK, PRKRIR, THAP0 |
| Background: |
| UniProt Protein Function: | PRKRIR: Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR- inhibitory function of P58IPK, resulting in restoration of kinase activity and suppression of cell growth. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protein kinase, regulatory subunit; Cell cycle regulation Chromosomal Location of Human Ortholog: 11q13.5 Cellular Component: nucleus Molecular Function:protein dimerization activity; DNA binding; metal ion binding Biological Process: negative regulation of cell proliferation; response to stress; signal transduction |
| UniProt Code: | O43422 |
| NCBI GenInfo Identifier: | 12643558 |
| NCBI Gene ID: | 5612 |
| NCBI Accession: | O43422.2 |
| UniProt Secondary Accession: | O43422,Q9CUX1, |
| UniProt Related Accession: | O43422 |
| Molecular Weight: | 1137 |
| NCBI Full Name: | 52 kDa repressor of the inhibitor of the protein kinase |
| NCBI Synonym Full Names: | protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) |
| NCBI Official Symbol: | PRKRIR |
| NCBI Official Synonym Symbols: | DAP4; THAP0; THAP12; P52rIPK |
| NCBI Protein Information: | 52 kDa repressor of the inhibitor of the protein kinase; THAP domain containing 12; death-associated protein 4; p58IPK-interacting protein; inhibitor of protein kinase PKR; THAP domain-containing protein 0; 58 kDa interferon-induced protein kinase-interac |
| UniProt Protein Name: | 52 kDa repressor of the inhibitor of the protein kinase |
| UniProt Synonym Protein Names: | 58 kDa interferon-induced protein kinase-interacting protein; p58IPK-interacting protein; Death-associated protein 4; THAP domain-containing protein 0 |
| Protein Family: | Dipeptidyl aminopeptidase |
| UniProt Gene Name: | PRKRIR |
| UniProt Entry Name: | P52K_HUMAN |
 | Western blot analysis of extracts of various cell lines, using THAP12 antibody (CAB15085) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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