Anti-TGM2 Antibody (CAB0981)
- SKU:
- CAB0981
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-TGM2 Antibody |
| Antibody SKU: | CAB0981 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human TGM2 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | SW480, A-549, DU145, PC-3 |
| Immunogen: | Recombinant protein of human TGM2 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7052 |
| Uniprot: | P21980 |
| Cellular Location: | |
| Calculated MW: | 38kDa/61kDa/77kDa |
| Observed MW: | 90kDa |
| Synonyms: | TGM2, TG(C), TGC |
| Background: | Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | TGM2: an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis.. Is the autoantigen in coeliac disease and plays a role in apoptosis, cellular differentiation and matrix stabilisation. Three alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:EC 2.3.2.13; Transferase Chromosomal Location of Human Ortholog: 20q12 Cellular Component: cytosol; focal adhesion; intrinsic to plasma membrane; mitochondrion Molecular Function:protein binding; protein-glutamine gamma-glutamyltransferase activity Biological Process: apoptotic cell clearance; elevation of mitochondrial calcium ion concentration; positive regulation of apoptosis; positive regulation of cell adhesion; reduction of endoplasmic reticulum calcium ion concentration |
| NCBI Summary: | Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P21980 |
| NCBI GenInfo Identifier: | 20141877 |
| NCBI Gene ID: | 7052 |
| NCBI Accession: | P21980.2 |
| UniProt Secondary Accession: | P21980,Q16436, Q6B838, Q9BTN7, Q9UH35, E1P5V9, |
| UniProt Related Accession: | P21980 |
| Molecular Weight: | 38,671 Da |
| NCBI Full Name: | Protein-glutamine gamma-glutamyltransferase 2 |
| NCBI Synonym Full Names: | transglutaminase 2 |
| NCBI Official Symbol: | TGM2 |
| NCBI Official Synonym Symbols: | TGC; TG(C) |
| NCBI Protein Information: | protein-glutamine gamma-glutamyltransferase 2 |
| UniProt Protein Name: | Protein-glutamine gamma-glutamyltransferase 2 |
| UniProt Synonym Protein Names: | Tissue transglutaminase; Transglutaminase C; TG(C); TGC; TGase C; Transglutaminase H; TGase H; Transglutaminase-2; TGase-2 |
| Protein Family: | Protein-glutamine gamma-glutamyltransferase |
| UniProt Gene Name: | TGM2 |
| UniProt Entry Name: | TGM2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TGM2 antibody (CAB0981) at 1:300 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded mouse brain using TGM2 antibody (CAB0981) (40x lens). |
 | Immunohistochemistry of paraffin-embedded human lung cancer using TGM2 antibody (CAB0981) (40x lens). |
 | Immunohistochemistry of paraffin-embedded human esophagus using TGM2 antibody (CAB0981) (40x lens). |