| UniProt Protein Function: | TGFBR3: Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. Interacts with TCTEX1D4. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1p33-p32 Cellular Component: proteinaceous extracellular matrix; extracellular space; cell surface; integral to plasma membrane; endoplasmic reticulum; receptor complex; external side of plasma membrane Molecular Function:heparin binding; transforming growth factor beta receptor activity; protein binding; fibroblast growth factor binding; glycosaminoglycan binding; transforming growth factor beta binding; punt binding; activin binding; coreceptor activity; SMAD binding; transforming growth factor beta receptor binding; PDZ domain binding Biological Process: transforming growth factor beta receptor complex assembly; heart morphogenesis; blood vessel development; cell migration; organ regeneration; blastocyst development; positive regulation of transforming growth factor beta receptor signaling pathway; cardiac muscle cell proliferation; negative regulation of cell motility; palate development; liver development; activation of NF-kappaB transcription factor; BMP signaling pathway; transforming growth factor beta receptor signaling pathway; regulation of protein binding; response to hypoxia; epithelial to mesenchymal transition; ventricular cardiac muscle morphogenesis; immune response; cell growth; negative regulation of transforming growth factor beta receptor signaling pathway; response to follicle-stimulating hormone stimulus; negative regulation of epithelial cell proliferation |
| NCBI Summary: | This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010] |
| UniProt Code: | Q03167 |
| NCBI GenInfo Identifier: | 307574634 |
| NCBI Gene ID: | 7049 |
| NCBI Accession: | NP_001182613.1 |
| UniProt Secondary Accession: | Q03167,Q5T2T4, Q5U731, Q9UGI2, A0AUW8, A8K5N0, B9EG88 |
| UniProt Related Accession: | Q03167 |
| Molecular Weight: | 93,499 Da |
| NCBI Full Name: | transforming growth factor beta receptor type 3 isoform b |
| NCBI Synonym Full Names: | transforming growth factor, beta receptor III |
| NCBI Official Symbol: | TGFBR3 |
| NCBI Official Synonym Symbols: | BGCAN; betaglycan |
| NCBI Protein Information: | transforming growth factor beta receptor type 3; TGFR-3; betaglycan proteoglycan; TGF-beta receptor type 3; TGF-beta receptor type III |
| UniProt Protein Name: | Transforming growth factor beta receptor type 3 |
| UniProt Synonym Protein Names: | Betaglycan; Transforming growth factor beta receptor III |
| UniProt Gene Name: | TGFBR3 |
| UniProt Entry Name: | TGBR3_HUMAN |
