Anti-TGFBI Antibody (CAB11222)
- SKU:
- CAB11222
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-TGFBI Antibody |
| Antibody SKU: | CAB11222 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 481-683 of human TGFBI (NP_000349.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BxPC-3, Mouse heart, Mouse kidney, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 481-683 of human TGFBI (NP_000349.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AHDK RGRY GTLF TMDR VLTP PMGT VMDV LKGD NRFS MLVA AIQS AGLT ETLN REGV YTVF APTN EAFR ALPP RERS RLLG DAKE LANI LKYH IGDE ILVS GGIG ALVR LKSL QGDK LEVS LKNN VVSV NKEP VAEP DIMA TNGV VHVI TNVL QPPA NRPQ ERGD ELAD SALE IFKQ ASAF SRAS QRSV RLAP VYQK LLER MKH |
| Gene ID: | 7045 |
| Uniprot: | Q15582 |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
| Calculated MW: | 74kDa |
| Observed MW: | 75kDa |
| Synonyms: | TGFBI, BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3, EBMD, LCD1 |
| Background: | This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. |
| UniProt Protein Function: | betaIG-H3: Binds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation. By TGFB1. Highly expressed in the corneal epithelium. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Cell adhesion; Secreted; Extracellular matrix Chromosomal Location of Human Ortholog: 5q31 Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; extracellular region; plasma membrane; basement membrane; trans-Golgi network Molecular Function:collagen binding; integrin binding; protein binding; extracellular matrix binding Biological Process: cell proliferation; extracellular matrix organization and biogenesis; visual perception; response to stimulus; chondrocyte differentiation; negative regulation of cell adhesion; angiogenesis; cell adhesion Disease: Corneal Dystrophy, Epithelial Basement Membrane; Corneal Dystrophy, Lattice Type Iiia; Corneal Dystrophy, Avellino Type; Corneal Dystrophy Of Bowman Layer, Type Ii; Corneal Dystrophy, Lattice Type I; Corneal Dystrophy Of Bowman Layer, Type I; Corneal Dystrophy, Groenouw Type I |
| NCBI Summary: | This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15582 |
| NCBI GenInfo Identifier: | 2498193 |
| NCBI Gene ID: | 7045 |
| NCBI Accession: | Q15582.1 |
| UniProt Secondary Accession: | Q15582,O14471, O14472, O14476, O43216, O43217, O43218 O43219, Q53XM1, D3DQB1, |
| UniProt Related Accession: | Q15582 |
| Molecular Weight: | 74,681 Da |
| NCBI Full Name: | Transforming growth factor-beta-induced protein ig-h3 |
| NCBI Synonym Full Names: | transforming growth factor, beta-induced, 68kDa |
| NCBI Official Symbol: | TGFBI |
| NCBI Official Synonym Symbols: | CSD; CDB1; CDG2; CSD1; CSD2; CSD3; EBMD; LCD1; BIGH3; CDGG1 |
| NCBI Protein Information: | transforming growth factor-beta-induced protein ig-h3; RGD-CAP; beta ig-h3; kerato-epithelin; RGD-containing collagen-associated protein; transforming growth factor, beta-induced, 68kD |
| UniProt Protein Name: | Transforming growth factor-beta-induced protein ig-h3 |
| UniProt Synonym Protein Names: | Kerato-epithelin; RGD-containing collagen-associated protein; RGD-CAP |
| Protein Family: | Transforming growth factor-beta-induced protein |
| UniProt Gene Name: | TGFBI |
| UniProt Entry Name: | BGH3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TGFBI antibody (CAB11222) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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