Anti-TFDP1 Antibody (CAB5422)
- SKU:
- CAB5422
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| Antibody Name: | Anti-TFDP1 Antibody |
| Antibody SKU: | CAB5422 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human TFDP1 (NP_009042.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | LO2, Raji, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human TFDP1 (NP_009042.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAKD AGLI EANG ELKV FIDQ NLSP GKGV VSLV AVHP STVN PLGK QLLP KTFG QSNV NIAQ QVVI GTPQ RPAA SNTL VVGS PHTP STHF ASQN QPSD SSPW SAGK RNRK GEKN GKGL RHFS MKVC EKVQ RKGT TSYN EVAD ELVA EFSA ADNH ILPN ESAY DQKN IRRR VYDA LNVL MAMN IISK EKKE IKWI GLPT NSAQ ECQN LEVE RQRR LERI KQKQ SQLQ ELIL QQIA FKNL VQRN RHAE QQAS RPPP PNSV IHLP FIIV NTSK KTVI DCSI SNDK FEYL FNFD NT |
| Gene ID: | 7027 |
| Uniprot: | Q14186 |
| Cellular Location: | Nucleus |
| Calculated MW: | 34kDa/45kDa |
| Observed MW: | 45kDa |
| Synonyms: | TFDP1, DILC, DP1, DRTF1, Dp-1 |
| Background: | This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X. |
| UniProt Protein Function: | TFDP1: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and apoptosis. Belongs to the E2F/DP family. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; DNA-binding Chromosomal Location of Human Ortholog: 13q34 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding; protein domain specific binding; transcription factor activity; transcription factor binding Biological Process: cell proliferation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009] |
| UniProt Code: | Q14186 |
| NCBI GenInfo Identifier: | 3122926 |
| NCBI Gene ID: | 7027 |
| NCBI Accession: | Q14186.1 |
| UniProt Secondary Accession: | Q14186,Q5JSB4, Q8IZL5, B4DLQ9, |
| UniProt Related Accession: | Q14186 |
| Molecular Weight: | 34,921 Da |
| NCBI Full Name: | Transcription factor Dp-1 |
| NCBI Synonym Full Names: | transcription factor Dp-1 |
| NCBI Official Symbol: | TFDP1 |
| NCBI Official Synonym Symbols: | DP1; DILC; Dp-1; DRTF1 |
| NCBI Protein Information: | transcription factor Dp-1 |
| UniProt Protein Name: | Transcription factor Dp-1 |
| UniProt Synonym Protein Names: | DRTF1-polypeptide 1; DRTF1; E2F dimerization partner 1 |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | TFDP1 |
| UniProt Entry Name: | TFDP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TFDP1 antibody (CAB5422) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human colon damage using TFDP1 antibody (CAB5422) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human lung using TFDP1 antibody (CAB5422) at dilution of 1:200 (40x lens). |
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