Anti-TERT Antibody (CAB16625)
- SKU:
- CAB16625
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-TERT Antibody |
| Antibody SKU: | CAB16625 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1000 to the C-terminus of human TERT (NP_937983.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1000 to the C-terminus of human TERT (NP_937983.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NIYK ILLL QAYR FHAC VLQL PFHQ QVWK NPTF FLRV ISDT ASLC YSIL KAKN AGMS LGAK GAAG PLPS EAVQ WLCH QAFL LKLT RHRV TYVP LLGS LRTA QTQL SRKL PGTT LTAL EAAA NPAL PSDF KTIL D |
| Gene ID: | 7015 |
| Uniprot: | O14746 |
| Cellular Location: | Chromosome, Cytoplasm, Nucleus, PML body, nucleolus, nucleoplasm, telomere |
| Calculated MW: | 88kDa/90kDa/120kDa/126kDa |
| Observed MW: | Refer to figures |
| Synonyms: | TERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT |
| Background: | Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. |
| UniProt Protein Function: | TERT: telomerase reverse transcriptase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The holoenzyme consists of TERT and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced isoforms have been identified, although the full-length sequence of some variants has not been determined. |
| UniProt Protein Details: | Protein type:Transferase; Nucleolus; EC 2.7.7.49; DNA-binding Chromosomal Location of Human Ortholog: 5p15.33 Cellular Component: nucleoplasm; PML body; chromosome, telomeric region; nuclear telomere cap complex; telomerase holoenzyme complex; nucleolus Molecular Function:telomerase activity; protein binding; protein homodimerization activity; RNA-directed RNA polymerase activity; DNA binding; metal ion binding; telomeric DNA binding; RNA-directed DNA polymerase activity; telomeric template RNA reverse transcriptase activity; nucleotidyltransferase activity; tRNA binding Biological Process: mitochondrion organization and biogenesis; DNA strand elongation; RNA-dependent DNA replication; positive regulation of nitric-oxide synthase activity; telomere maintenance via telomerase; age-dependent telomere shortening; positive regulation of Wnt receptor signaling pathway; RNA interference, production of siRNA; telomere maintenance Disease: Pulmonary Fibrosis, Idiopathic; Aplastic Anemia; Dyskeratosis Congenita, Autosomal Dominant, 1 |
| NCBI Summary: | Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14746 |
| NCBI GenInfo Identifier: | 6226780 |
| NCBI Gene ID: | 7015 |
| NCBI Accession: | O14746.1 |
| UniProt Secondary Accession: | O14746,O14783, Q2XS35, Q8N6C3, Q8NG38, Q8NG46, |
| UniProt Related Accession: | O14746 |
| Molecular Weight: | 88,965 Da |
| NCBI Full Name: | Telomerase reverse transcriptase |
| NCBI Synonym Full Names: | telomerase reverse transcriptase |
| NCBI Official Symbol: | TERT |
| NCBI Official Synonym Symbols: | TP2; TRT; CMM9; EST2; TCS1; hTRT; DKCA2; DKCB4; hEST2; PFBMFT1 |
| NCBI Protein Information: | telomerase reverse transcriptase; telomerase catalytic subunit; telomerase-associated protein 2 |
| UniProt Protein Name: | Telomerase reverse transcriptase |
| UniProt Synonym Protein Names: | HEST2; Telomerase catalytic subunit; Telomerase-associated protein 2; TP2 |
| Protein Family: | Telomerase reverse transcriptase |
| UniProt Gene Name: | TERT |
| UniProt Entry Name: | TERT_HUMAN |
 | Immunohistochemistry of paraffin-embedded human breast cancer using TERT antibody (CAB16625) at dilution of 1:100 (40x lens). |
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