Anti-TEAD2 Antibody (CAB15594)
- SKU:
- CAB15594
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-TEAD2 Antibody |
| Antibody SKU: | CAB15594 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human TEAD2 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | A-431 |
| Immunogen: | Recombinant protein of human TEAD2 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8463 |
| Uniprot: | Q15562 |
| Cellular Location: | |
| Calculated MW: | 35kDa/49kDa |
| Observed MW: | 51KDa |
| Synonyms: | TEAD2, ETF, TEAD-2, TEF-4, TEF4 |
| Background: |
| UniProt Protein Function: | TEAD2: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'- GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. Interacts with YAP1 and WWTR1/TAZ. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: nucleoplasm Molecular Function:protein binding; transcription factor activity Biological Process: transcription initiation from RNA polymerase II promoter |
| UniProt Code: | Q15562 |
| NCBI GenInfo Identifier: | 21264529 |
| NCBI Gene ID: | 8463 |
| NCBI Accession: | Q15562.2 |
| UniProt Secondary Accession: | Q15562,Q8NA25, Q96IG3, B4DTJ6, M0R1T9, |
| UniProt Related Accession: | Q15562 |
| Molecular Weight: | 49,640 Da |
| NCBI Full Name: | Transcriptional enhancer factor TEF-4 |
| NCBI Synonym Full Names: | TEA domain transcription factor 2 |
| NCBI Official Symbol: | TEAD2 |
| NCBI Official Synonym Symbols: | ETF; TEF4; TEF-4; TEAD-2 |
| NCBI Protein Information: | transcriptional enhancer factor TEF-4 |
| UniProt Protein Name: | Transcriptional enhancer factor TEF-4 |
| UniProt Synonym Protein Names: | TEA domain family member 2; TEAD-2 |
| Protein Family: | Transcriptional enhancer factor |
| UniProt Gene Name: | TEAD2 |
| UniProt Entry Name: | TEAD2_HUMAN |
 | Western blot analysis of extracts of A-431 cells, using HSPB7 antibody (CAB15594) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
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