Anti-TDO2 Antibody (CAB6766)
- SKU:
- CAB6766
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-TDO2 Antibody |
| Antibody SKU: | CAB6766 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 137-406 of human TDO2 (NP_005642.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, U-937, SKOV3, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 137-406 of human TDO2 (NP_005642.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ALDF NDFR EYLS PASG FQSL QFRL LENK IGVL QNMR VPYN RRHY RDNF KGEE NELL LKSE QEKT LLEL VEAW LERT PGLE PHGF NFWG KLEK NITR GLEE EFIR IQAK EESE EKEE QVAE FQKQ KEVL LSLF DEKR HEHL LSKG ERRL SYRA LQGA LMIY FYRE EPRF QVPF QLLT SLMD IDSL MTKW RYNH VCMV HRML GSKA GTGG SSGY HYLR STVS DRYK VFVD LFNL STYL IPRH WIPK MNPT IHKF LYTA EYCD SSYF SSDE SD |
| Gene ID: | 6999 |
| Uniprot: | P48775 |
| Cellular Location: | |
| Calculated MW: | 47kDa |
| Observed MW: | 48kDa |
| Synonyms: | TDO2, TDO, TO, TPH2, TRPO, tryptophan 2 |
| Background: | This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. |
| UniProt Protein Function: | TDO2: Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin. Belongs to the tryptophan 2,3-dioxygenase family. |
| UniProt Protein Details: | Protein type:Amino Acid Metabolism - tryptophan; Oxidoreductase; EC 1.13.11.11 Chromosomal Location of Human Ortholog: 4q31-q32 Cellular Component: cytosol Molecular Function:heme binding; protein binding; tryptophan 2,3-dioxygenase activity Biological Process: tryptophan catabolic process; tryptophan catabolic process to acetyl-CoA |
| NCBI Summary: | This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012] |
| UniProt Code: | P48775 |
| NCBI GenInfo Identifier: | 1351188 |
| NCBI Gene ID: | 6999 |
| NCBI Accession: | P48775.1 |
| UniProt Secondary Accession: | P48775,A8K053, |
| UniProt Related Accession: | P48775 |
| Molecular Weight: | 47,872 Da |
| NCBI Full Name: | Tryptophan 2,3-dioxygenase |
| NCBI Synonym Full Names: | tryptophan 2,3-dioxygenase |
| NCBI Official Symbol: | TDO2 |
| NCBI Official Synonym Symbols: | TO; TDO; TPH2; TRPO |
| NCBI Protein Information: | tryptophan 2,3-dioxygenase |
| UniProt Protein Name: | Tryptophan 2,3-dioxygenase |
| UniProt Synonym Protein Names: | Tryptamin 2,3-dioxygenase |
| UniProt Gene Name: | TDO2 |
| UniProt Entry Name: | T23O_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TDO2 antibody (CAB6766) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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