Anti-TAX1BP3 Antibody (CAB8750)
- SKU:
- CAB8750
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-TAX1BP3 Antibody |
| Antibody SKU: | CAB8750 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-124 of human TAX1BP3 (NP_055419.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-124 of human TAX1BP3 (NP_055419.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSYI PGQP VTAV VQRV EIHK LRQG ENLI LGFS IGGG IDQD PSQN PFSE DKTD KGIY VTRV SEGG PAEI AGLQ IGDK IMQV NGWD MTMV THDQ ARKR LTKR SEEV VRLL VTRQ SLQK AVQQ SMLS |
| Gene ID: | 30851 |
| Uniprot: | O14907 |
| Cellular Location: | Cell membrane, Cytoplasm, Cytoplasmic side, Nucleus, Peripheral membrane protein |
| Calculated MW: | 13kDa |
| Observed MW: | 14kDa |
| Synonyms: | TAX1BP3, TIP-1, TIP1 |
| Background: | This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| UniProt Protein Function: | TAX1BP3: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Adaptor/scaffold Chromosomal Location of Human Ortholog: 17p13 Cellular Component: cytosol Molecular Function:protein binding; protein C-terminus binding Biological Process: negative regulation of Wnt receptor signaling pathway; Rho protein signal transduction |
| UniProt Code: | O14907 |
| NCBI GenInfo Identifier: | 74739481 |
| NCBI Gene ID: | 30851 |
| NCBI Accession: | O14907.2 |
| UniProt Secondary Accession: | O14907,Q7LCQ4, B2RD53, D3DTJ6, |
| UniProt Related Accession: | O14907 |
| Molecular Weight: | 13,735 Da |
| NCBI Full Name: | Tax1-binding protein 3 |
| NCBI Synonym Full Names: | Tax1 binding protein 3 |
| NCBI Official Symbol: | TAX1BP3 |
| NCBI Official Synonym Symbols: | TIP1; TIP-1 |
| NCBI Protein Information: | tax1-binding protein 3 |
| UniProt Protein Name: | Tax1-binding protein 3 |
| UniProt Synonym Protein Names: | Glutaminase-interacting protein 3; Tax interaction protein 1; TIP-1; Tax-interacting protein 1 |
| UniProt Gene Name: | TAX1BP3 |
| UniProt Entry Name: | TX1B3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TAX1BP3 antibody (CAB8750) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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