Anti-TAX1BP1 Antibody (CAB17039)
- SKU:
- CAB17039
- Product type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| Antibody Name: | Anti-TAX1BP1 Antibody |
| Antibody SKU: | CAB17039 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 709-789 of human TAX1BP1 (NP_006015.4). |
| Application: | IHC |
| Recommended Dilution: | IHC 1:50 - 1:200 |
| Reactivity: | Human, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 709-789 of human TAX1BP1 (NP_006015.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QHLR GHGT GFCF DSSF DVHK KCPL CELM FPPN YDQS KFEE HVES HWKV CPMC SEQF PPDY DQQV FERH VQTH FDQN VLNF D |
| Gene ID: | 8887 |
| Uniprot: | Q86VP1 |
| Cellular Location: | |
| Calculated MW: | 65kDa/68kDa/86kDa/90kDa |
| Observed MW: | Refer to figures |
 | Immunohistochemistry - TAX1BP1 Polyclonal Antibody (CAB17039) |
| Synonyms: | TAX1BP1, CALCOCO3, T6BP, TXBP151 |
| Background: | This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | TAX1BP1: Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with TNFAIP3. Interacts with STARD13. Interacts with the HTLV-1 protein Tax-1. Expressed in all tissues tested. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Apoptosis Chromosomal Location of Human Ortholog: 7p15 Cellular Component: cytosol Molecular Function:kinase binding; protein binding Biological Process: inhibition of NF-kappaB transcription factor; negative regulation of interferon type I production |
| NCBI Summary: | This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011] |
| UniProt Code: | Q86VP1 |
| NCBI GenInfo Identifier: | 97202549 |
| NCBI Gene ID: | 8887 |
| NCBI Accession: | Q86VP1.2 |
| UniProt Secondary Accession: | Q86VP1,O60398, O95770, Q13311, Q9BQG5, Q9UI88, A4D196 B4DKU7, E7ENV2, |
| UniProt Related Accession: | Q86VP1 |
| Molecular Weight: | 68,277 Da |
| NCBI Full Name: | Tax1-binding protein 1 |
| NCBI Synonym Full Names: | Tax1 binding protein 1 |
| NCBI Official Symbol: | TAX1BP1 |
| NCBI Official Synonym Symbols: | T6BP; TXBP151; CALCOCO3 |
| NCBI Protein Information: | tax1-binding protein 1 |
| UniProt Protein Name: | Tax1-binding protein 1 |
| UniProt Synonym Protein Names: | TRAF6-binding protein |
| Protein Family: | Tax1-binding protein |
| UniProt Gene Name: | TAX1BP1 |
| UniProt Entry Name: | TAXB1_HUMAN |
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