Anti-TAT Antibody (CAB6764)
- SKU:
- CAB6764
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-TAT Antibody |
| Antibody SKU: | CAB6764 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human TAT (NP_000344.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BT-474, Raji, A673, HepG2, Mouse liver, Mouse kidney, Mouse heart, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human TAT (NP_000344.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDPY MIQM SSKG NLPS ILDV HVNV GGRS SVPG KMKG RKAR WSVR PSDM AKKT FNPI RAIV DNMK VKPN PNKT MISL SIGD PTVF GNLP TDPE VTQA MKDA LDSG KYNG YAPS IGFL SSRE EIAS YYHC PEAP LEAK DVIL TSGC SQAI DLCL AVLA NPGQ NILV PRPG FSLY KTLA ESMG IEVK LYNL LPEK SWEI DLKQ LEYL IDEK TACL IVNN PSNP CGSV FSKR HLQK ILAV AARQ CVPI LADE IYGD MVFS DCKY EPLA TLST DV |
| Gene ID: | 6898 |
| Uniprot: | P17735 |
| Cellular Location: | |
| Calculated MW: | 50kDa |
| Observed MW: | 55kDa |
| Synonyms: | TAT |
| Background: | This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible mental retardation. A regulator gene for tyrosine aminotransferase is X-linked. |
| UniProt Protein Function: | TAT: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. Defects in TAT are the cause of tyrosinemia type 2 (TYRO2); also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. |
| UniProt Protein Details: | Protein type:Cofactor and Vitamin Metabolism - ubiquinone and other terpenoid-quinone biosynthesis; Mitochondrial; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - phenylalanine; EC 2.6.1.5; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Amino Acid Metabolism - cysteine and methionine; Transferase Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: mitochondrion; cytosol Molecular Function:amino acid binding; tyrosine transaminase activity; pyridoxal phosphate binding Biological Process: response to mercury ion; L-phenylalanine catabolic process; glutamate metabolic process; tyrosine catabolic process; response to glucocorticoid stimulus; biosynthetic process; response to oxidative stress; 2-oxoglutarate metabolic process Disease: Tyrosinemia, Type Ii |
| NCBI Summary: | This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible mental retardation. A regulator gene for tyrosine aminotransferase is X-linked. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P17735 |
| NCBI GenInfo Identifier: | 114713 |
| NCBI Gene ID: | 6898 |
| NCBI Accession: | P17735.1 |
| UniProt Secondary Accession: | P17735,B2R8I1, D3DWS2, |
| UniProt Related Accession: | P17735 |
| Molecular Weight: | 454 |
| NCBI Full Name: | Tyrosine aminotransferase |
| NCBI Synonym Full Names: | tyrosine aminotransferase |
| NCBI Official Symbol: | TAT |
| NCBI Protein Information: | tyrosine aminotransferase; tyrosine aminotransferase, cytosolic; L-tyrosine:2-oxoglutarate aminotransferase |
| UniProt Protein Name: | Tyrosine aminotransferase |
| UniProt Synonym Protein Names: | L-tyrosine:2-oxoglutarate aminotransferase |
| Protein Family: | Tat-binding |
| UniProt Gene Name: | TAT |
| UniProt Entry Name: | ATTY_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TAT antibody (CAB6764) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5min. |
 | Immunofluorescence analysis of MCF-7 cells using TAT antibody (CAB6764). Blue: DAPI for nuclear staining. |
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