Anti-TARBP2 Antibody (CAB7533)

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SKU:
CAB7533
Product type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
Frequently bought together:

Description

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Antibody Name:Anti-TARBP2 Antibody
Antibody SKU:CAB7533
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-366 of human TARBP2 (NP_599150.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:HeLa, HepG2, Mouse testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-366 of human TARBP2 (NP_599150.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSEE EQGS GTTT GCGL PSIE QMLA ANPG KTPI SLLQ EYGT RIGK TPVY DLLK AEGQ AHQP NFTF RVTV GDTS CTGQ GPSK KAAK HKAA EVAL KHLK GGSM LEPA LEDS SSFS PLDS SLPE DIPV FTAA AAAT PVPS VVLT RSPP MELQ PPVS PQQS ECNP VGAL QELV VQKG WRLP EYTV TQES GPAH RKEF TMTC RVER FIEI GSGT SKKL AKRN AAAK MLLR VHTV PLDA RDGN EVEP DDDH FSIG VGSR LDGL RNRG PGCT WDSL RNSV GEKI LSLR SCSL GSLG ALGP ACCR VLSE LSEE QAFH VSYL DIEE LSLS GLCQ CLVE LSTQ PATV CHGS ATTR EAAR GEAA RRAL QYLK IMAG SK
Gene ID:6895
Uniprot:Q15633
Cellular Location:Cytoplasm, Nucleus, perinuclear region
Calculated MW:36kDa/39kDa
Observed MW:46kDa
Synonyms:TARBP2, LOQS, TRBP, TRBP1, TRBP2
Background:HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene.
UniProt Protein Function:TRBP: the HIV-1 TAR RNA binding protein (TRBP) is a double strand RNA binding protein (dsRBP) that is required for the recruitment of Ago2 to the small interfering RNA (siRNA) bound by Dicer. TRBP increases HIV-1 expression and replication by inhibiting the interferon-induced protein kinase PKR and by increasing translation of viral mRNA. Dicer, Ago2, and TRBP are the main components of the RNA-induced silencing complex (RISC).
UniProt Protein Details:

Protein type:Translation; Motility/polarity/chemotaxis; RNA processing; RNA-binding

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytoplasm; nucleus; cytosol

Molecular Function:protein binding; siRNA binding; protein homodimerization activity; miRNA binding; double-stranded RNA binding

Biological Process: regulation of transcription from RNA polymerase II promoter; regulation of translation; positive regulation of viral genome replication; regulation of transcription, DNA-dependent; pre-microRNA processing; regulation of viral transcription; RNA interference, targeting of mRNA for destruction; miRNA-mediated gene silencing, miRNA loading onto RISC; negative regulation of protein kinase activity; gene expression; negative regulation of defense response to virus by host; RNA interference, production of siRNA

NCBI Summary:HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008]
UniProt Code:Q15633
NCBI GenInfo Identifier:209572714
NCBI Gene ID:6895
NCBI Accession:Q15633.3
UniProt Related Accession:Q15633
Molecular Weight:39kDa
NCBI Full Name:RISC-loading complex subunit TARBP2
NCBI Synonym Full Names:TARBP2 subunit of RISC loading complex
NCBI Official Symbol:TARBP2  
NCBI Official Synonym Symbols:LOQS; TRBP; TRBP1; TRBP2  
NCBI Protein Information:RISC-loading complex subunit TARBP2
UniProt Protein Name:RISC-loading complex subunit TARBP2
UniProt Synonym Protein Names:TAR RNA-binding protein 2; Trans-activation-responsive RNA-binding protein
UniProt Gene Name:TARBP2  
UniProt Entry Name:TRBP2_HUMAN
Anti-TARBP2 Antibody (CAB7533)Western blot analysis of extracts of various cell lines, using TARBP2 antibody (CAB7533) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-TARBP2 Antibody (CAB7533)Immunohistochemistry of paraffin-embedded human thyroid cancer using TARBP2 Rabbit pAb (CAB7533) at dilution of 1:200 (40x lens).
Anti-TARBP2 Antibody (CAB7533)Immunohistochemistry of paraffin-embedded human breast cancer using TARBP2 Rabbit pAb (CAB7533) at dilution of 1:200 (40x lens).
Anti-TARBP2 Antibody (CAB7533)Immunofluorescence analysis of A549 cells using TARBP2 antibody (CAB7533).

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