Anti-TALDO1 Antibody (CAB13551)
- SKU:
- CAB13551
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-TALDO1 Antibody |
| Antibody SKU: | CAB13551 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-337 of human TALDO1 (NP_006746.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, A-431, HL-60, SW480, Mouse brain, Mouse kidney, Rat liver, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-337 of human TALDO1 (NP_006746.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSSS PVKR QRME SALD QLKQ FTTV VADT GDFH AIDE YKPQ DATT NPSL ILAA AQMP AYQE LVEE AIAY GRKL GGSQ EDQI KNAI DKLF VLFG AEIL KKIP GRVS TEVD ARLS FDKD AMVA RARR LIEL YKEA GISK DRIL IKLS STWE GIQA GKEL EEQH GIHC NMTL LFSF AQAV ACAE AGVT LISP FVGR ILDW HVAN TDKK SYEP LEDP GVKS VTKI YNYY KKFS YKTI VMGA SFRN TGEI KALA GCDF LTIS PKLL GELL QDNA KLVP VLSA KAAQ ASDL EKIH LDEK SFRW LHNE DQMA VEKL SDGI RKFA ADAV KLER MLTE RMFN AENG K |
| Gene ID: | 6888 |
| Uniprot: | P37837 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 37kDa |
| Observed MW: | 37kDa |
| Synonyms: | TALDO1, TAL, TAL-H, TALDOR, TALH |
| Background: | Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. |
| UniProt Protein Function: | TALDO1: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Defects in TALDO1 are the cause of transaldolase 1 deficiency (TALDO1 deficiency). It results in telangiectases of the skin, hepatosplenomegaly, and enlarged clitoris. Belongs to the transaldolase family. Type 1 subfamily. |
| UniProt Protein Details: | Protein type:Transferase; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.2.1.2 Chromosomal Location of Human Ortholog: 11p15.5-p15.4 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:protein binding; transaldolase activity Biological Process: carbohydrate metabolic process; pentose-phosphate shunt; xylulose biosynthetic process Disease: Transaldolase Deficiency |
| NCBI Summary: | Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P37837 |
| NCBI GenInfo Identifier: | 6648092 |
| NCBI Gene ID: | 6888 |
| NCBI Accession: | P37837.2 |
| UniProt Secondary Accession: | P37837,O00751, Q8WV32, Q8WZ45, B2R8M2, |
| UniProt Related Accession: | P37837 |
| Molecular Weight: | 37,540 Da |
| NCBI Full Name: | Transaldolase |
| NCBI Synonym Full Names: | transaldolase 1 |
| NCBI Official Symbol: | TALDO1 |
| NCBI Official Synonym Symbols: | TAL; TALH; TAL-H; TALDOR |
| NCBI Protein Information: | transaldolase |
| UniProt Protein Name: | Transaldolase |
| Protein Family: | Transaldolase |
| UniProt Gene Name: | TALDO1 |
| UniProt Entry Name: | TALDO_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TALDO1 antibody (CAB13551) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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