Anti-Tafazzin / TAZ Antibody (CAB12722)
- SKU:
- CAB12722
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| Antibody Name: | Anti-Tafazzin / TAZ Antibody |
| Antibody SKU: | CAB12722 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 174-248 of human Tafazzin / TAZ (NP_851830.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | H460, Mouse heart, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 174-248 of human Tafazzin / TAZ (NP_851830.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NDVL PNSP PYFP RFGQ KITV LIGK PFSA LPVL ERLR AENK SAVE MRKA LTDF IQEE FQHL KTQA EQLH NHLQ PGR |
| Gene ID: | 6901 |
| Uniprot: | Q16635 |
| Cellular Location: | Cytoplasm, Membrane, Single-pass membrane protein, Single-pass membrane protein |
| Calculated MW: | 25kDa/27kDa/28kDa/29kDa/30kDa/31kDa/33kDa |
| Observed MW: | 50kDa |
| Synonyms: | TAZ, BTHS, CMD3A, EFE, EFE2, G4.5, LVNCX, Taz1, tafazzin |
| Background: | This gene encodes a protein that is expressed at high levels in cardiac and skeletal muscle. Mutations in this gene have been associated with a number of clinical disorders including Barth syndrome, dilated cardiomyopathy (DCM), hypertrophic DCM, endocardial fibroelastosis, and left ventricular noncompaction (LVNC). Multiple transcript variants encoding different isoforms have been described. A long form and a short form of each of these isoforms is produced; the short form lacks a hydrophobic leader sequence and may exist as a cytoplasmic protein rather than being membrane-bound. Other alternatively spliced transcripts have been described but the full-length nature of all these transcripts is not known. |
| UniProt Protein Function: | tafazzin: Some isoforms may be involved in cardiolipin (CL) metabolism. Defects in TAZ are the cause of Barth syndrome (BTHS). An X-linked disease characterized by dilated cardiomyopathy with endocardial fibroelastosis, a predominantly proximal skeletal myopathy, growth retardation, neutropenia, and organic aciduria, particularly excess of 3-methylglutaconic acid. Additional features include hypertrophic cardiomyopathy, isolated left ventricular non-compaction, ventricular arrhythmia, motor delay, poor appetite, fatigue and exercise intolerance, hypoglycemia, lactic acidosis, hyperammonemia, and dramatic late catch-up growth after growth delay throughout childhood. Belongs to the taffazin family. 9 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transferase; Mitochondrial; Membrane protein, integral Chromosomal Location of Human Ortholog: Xq28 Cellular Component: mitochondrion; mitochondrial membrane; mitochondrial inner membrane; integral to membrane; intrinsic to membrane; cytosol; nucleus Molecular Function:1-acylglycerophosphocholine O-acyltransferase activity Biological Process: cardiolipin biosynthetic process; cardiac muscle development; mitochondrial respiratory chain complex I assembly; skeletal muscle development; muscle contraction; cristae formation; phospholipid metabolic process; heart development; glycerophospholipid biosynthetic process; hemopoiesis; cardiac muscle contraction; organelle ATP synthesis coupled electron transport Disease: Barth Syndrome |
| NCBI Summary: | This gene encodes a protein that is expressed at high levels in cardiac and skeletal muscle. Mutations in this gene have been associated with a number of clinical disorders including Barth syndrome, dilated cardiomyopathy (DCM), hypertrophic DCM, endocardial fibroelastosis, and left ventricular noncompaction (LVNC). Multiple transcript variants encoding different isoforms have been described. A long form and a short form of each of these isoforms is produced; the short form lacks a hydrophobic leader sequence and may exist as a cytoplasmic protein rather than being membrane-bound. Other alternatively spliced transcripts have been described but the full-length nature of all these transcripts is not known. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16635 |
| NCBI GenInfo Identifier: | 2498992 |
| NCBI Gene ID: | 6901 |
| NCBI Accession: | Q16635.1 |
| UniProt Secondary Accession: | Q16635,Q5HY43, Q5HY44, Q5HY45, Q5HY48, Q86XQ6, Q86XQ7 Q86XQ8, Q86XQ9, Q86XR0, A3KQT2, D3DWX2, |
| UniProt Related Accession: | Q16635 |
| Molecular Weight: | 25,836 Da |
| NCBI Full Name: | Tafazzin |
| NCBI Synonym Full Names: | tafazzin |
| NCBI Official Symbol: | TAZ |
| NCBI Official Synonym Symbols: | EFE; BTHS; EFE2; G4.5; Taz1; CMD3A; LVNCX |
| NCBI Protein Information: | tafazzin; protein G4.5 |
| UniProt Protein Name: | Tafazzin |
| UniProt Synonym Protein Names: | Protein G4.5 |
| Protein Family: | Tafazzin |
| UniProt Gene Name: | TAZ |
| UniProt Entry Name: | TAZ_HUMAN |
 | Western blot analysis of extracts of various cell lines, using Tafazzin / TAZ antibody (CAB12722) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 40s. |
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