Anti-TACR3 Antibody (CAB7220)
- SKU:
- CAB7220
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-TACR3 Antibody |
| Antibody SKU: | CAB7220 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 356-465 of human TACR3 (NP_001050.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HL-60, Human placenta |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 356-465 of human TACR3 (NP_001050.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YCCL NKRF RAGF KRAF RWCP FIKV SSYD ELEL KTTR FHPN RQSS MYTV TRME SMTV VFDP NDAD TTRS SRKK RATP RDPS FNGC SRRN SKSA SATS SFIS SPYT SVDE YS |
| Gene ID: | 6870 |
| Uniprot: | P29371 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 52kDa |
| Observed MW: | 52kDa |
| Synonyms: | TACR3, HH11, NK-3R, NK3R, NKR, TAC3RL |
| Background: | This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. |
| UniProt Protein Function: | TACR3: This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR Chromosomal Location of Human Ortholog: 4q25 Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; nucleus Molecular Function:protein binding; tachykinin receptor activity Biological Process: tachykinin signaling pathway; hyperosmotic salinity response; regulation of dopamine metabolic process; response to morphine; positive regulation of heart rate; response to cocaine; response to estradiol stimulus; positive regulation of blood pressure; aging Disease: Hypogonadotropic Hypogonadism 11 With Or Without Anosmia |
| NCBI Summary: | This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P29371 |
| NCBI GenInfo Identifier: | 128364 |
| NCBI Gene ID: | 6870 |
| NCBI Accession: | P29371.1 |
| UniProt Secondary Accession: | P29371,Q0P510, |
| UniProt Related Accession: | P29371 |
| Molecular Weight: | Calculated: 52kDaObserved: 50kDa |
| NCBI Full Name: | Neuromedin-K receptor |
| NCBI Synonym Full Names: | tachykinin receptor 3 |
| NCBI Official Symbol: | TACR3 |
| NCBI Official Synonym Symbols: | NKR; HH11; NK3R; NK-3R; TAC3RL |
| NCBI Protein Information: | neuromedin-K receptor; NK-3 receptor; neurokinin B receptor; neurokinin beta receptor |
| UniProt Protein Name: | Neuromedin-K receptor |
| UniProt Synonym Protein Names: | NK-3 receptor; NK-3R; Neurokinin B receptor; Tachykinin receptor 3 |
| Protein Family: | Neuromedin-K receptor |
| UniProt Gene Name: | TACR3 |
| UniProt Entry Name: | NK3R_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TACR3 antibody (CAB7220) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human stomach cancer using TACR3 antibody (CAB7220) at dilution of 1:100 (40x lens). |
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