Anti-TAB2 Antibody (CAB9867)
- SKU:
- CAB9867
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-TAB2 Antibody |
| Antibody SKU: | CAB9867 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-693 of human TAB2 (NP_001278963.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, HepG2, MCF7, HT-1080, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-693 of human TAB2 (NP_001278963.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | STSS SVNS QTLN RNQP TVYI AASP PNTD ELMS RSQP KVYI SANA ATGD EQVM RNQP TLFI STNS GASA ASRN MSGQ VSMG PAFI HHHP PKSR AIGN NSAT SPRV VVTQ PNTK YTFK ITVS PNKP PAVS PGVV SPTF ELTN LLNH PDHY VETE NIQH LTDP TLAH VDRI SETR KLSM GSDD AAYT QALL VHQK ARME RLQR ELEI QKKK LDKL KSEV NEME NNLT RRRL KRSN SISQ IPSL EEMQ QLRS CNRQ LQID IDCL TKEI DLFQ ARGP HFNP SAIH NFYD NIGF VGPV PPKP KDQR SIIK TPKT QDTE DDEG AQWN CTAC TFLN HPAL IRCE QCEM PRHF |
| Gene ID: | 23118 |
| Uniprot: | Q9NYJ8 |
| Cellular Location: | Cytoplasm, Membrane, Peripheral membrane protein, cytosol |
| Calculated MW: | 58kDa/76kDa |
| Observed MW: | 80kDa |
| Synonyms: | TAB2, CHTD2, MAP3K7IP2, TAB-2 |
| Background: | The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | TAB2: Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development. Interacts with MAP3K7 and TRAF6. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with NCOR1 and HDAC3 to form a ternary complex. Interacts (via C-terminal) with NUMBL (via PTB domain). Interacts (via the C-terminus) with WDR34 (via WD domains). Interacts with RBCK1. Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 6q25.1 Cellular Component: cytosol; endosome membrane; plasma membrane Molecular Function:protein binding Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; heart development; I-kappaB kinase/NF-kappaB cascade; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; negative regulation of autophagy; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein kinase activity; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway Disease: Congenital Heart Defects, Multiple Types, 2 |
| NCBI Summary: | The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
| UniProt Code: | Q9NYJ8 |
| NCBI GenInfo Identifier: | 74753070 |
| NCBI Gene ID: | 23118 |
| NCBI Accession: | Q9NYJ8.1 |
| UniProt Secondary Accession: | Q9NYJ8,O94838, Q6I9W8, Q76N06, Q9UFP7, B2RCC4, E1P5A0 |
| UniProt Related Accession: | Q9NYJ8 |
| Molecular Weight: | 76kDa |
| NCBI Full Name: | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 |
| NCBI Synonym Full Names: | TGF-beta activated kinase 1/MAP3K7 binding protein 2 |
| NCBI Official Symbol: | TAB2 |
| NCBI Official Synonym Symbols: | CHTD2; TAB-2; MAP3K7IP2 |
| NCBI Protein Information: | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 |
| UniProt Protein Name: | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 |
| UniProt Synonym Protein Names: | Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TAK1-binding protein 2; TAB-2; TGF-beta-activated kinase 1-binding protein 2 |
| Protein Family: | TGF-beta-activated kinase 1 and MAP3K7-binding protein |
| UniProt Gene Name: | TAB2 |
 | Western blot analysis of extracts of various cell lines, using TAB2 antibody (CAB9867) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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