Anti-STXBP1 Antibody (CAB9309)
- SKU:
- CAB9309
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-STXBP1 Antibody |
| Antibody SKU: | CAB9309 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human STXBP1 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa |
| Immunogen: | A synthesized peptide derived from human STXBP1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6812 |
| Uniprot: | P61764 |
| Cellular Location: | |
| Calculated MW: | 65kDa |
| Observed MW: | 70KDa |
| Synonyms: | MUNC18-1, NSEC1, P67, RBSEC1, UNC18 |
| Background: | This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010] |
| UniProt Protein Function: | STXBP1: may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. Two splice-variant isoforms have been described. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 9q34.1 Cellular Component: cytoplasm; cytosol; mitochondrion; myelin sheath; nucleoplasm; plasma membrane; protein complex; terminal button Molecular Function:identical protein binding; protein binding; protein domain specific binding; protein kinase binding; protein N-terminus binding; SNARE binding; syntaxin binding; syntaxin-1 binding Biological Process: axon target recognition; energy reserve metabolic process; glutamate secretion; negative regulation of neuron apoptosis; negative regulation of synaptic transmission, GABAergic; neuromuscular synaptic transmission; neurotransmitter secretion; platelet degranulation; positive regulation of calcium ion-dependent exocytosis; protein stabilization; protein transport; regulation of insulin secretion; regulation of synaptic vesicle fusion to presynaptic membrane; synaptic transmission; synaptic vesicle maturation; vesicle docking during exocytosis Disease: Epileptic Encephalopathy, Early Infantile, 4 |
| NCBI Summary: | This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010] |
| UniProt Code: | P61764 |
| NCBI GenInfo Identifier: | 50403646 |
| NCBI Gene ID: | 6812 |
| NCBI Accession: | P61764.1 |
| UniProt Secondary Accession: | P61764,Q28208, Q62759, Q64320, Q96TG8, B1AM97, |
| UniProt Related Accession: | P61764 |
| Molecular Weight: | 68,736 Da |
| NCBI Full Name: | Syntaxin-binding protein 1 |
| NCBI Synonym Full Names: | syntaxin binding protein 1 |
| NCBI Official Symbol: | STXBP1 |
| NCBI Official Synonym Symbols: | P67; NSEC1; UNC18; RBSEC1; MUNC18-1 |
| NCBI Protein Information: | syntaxin-binding protein 1 |
| UniProt Protein Name: | Syntaxin-binding protein 1 |
| UniProt Synonym Protein Names: | MUNC18-1; N-Sec1; Protein unc-18 homolog 1; Unc18-1; Protein unc-18 homolog A; Unc-18A; p67 |
| Protein Family: | Syntaxin-binding protein |
| UniProt Gene Name: | STXBP1 |
| UniProt Entry Name: | STXB1_HUMAN |
 | Western blot - STXBP1 Rabbit mAb (CAB9309) |
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