Anti-STX2 Antibody (CAB10444)
- SKU:
- CAB10444
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-STX2 Antibody |
| Antibody SKU: | CAB10444 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-264 of human STX2 (NP_001971.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | K-562, DU145, SKOV3, A-549, Mouse heart, Mouse testis, Rat liver, Rat heart, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-264 of human STX2 (NP_001971.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MRDR LPDL TACR KNDD GDTV VVVE KDHF MDDF FHQV EEIR NSID KITQ YVEE VKKN HSII LSAP NPEG KIKE ELED LNKE IKKT ANKI RAKL KAIE QSFD QDES GNRT SVDL RIRR TQHS VLSR KFVE AMAE YNEA QTLF RERS KGRI QRQL EITG RTTT DDEL EEML ESGK PSIF TSDI ISDS QITR QALN EIES RHKD IMKL ETSI RELH EMFM DMAM FVET QGEM INNI ERNV MNAT DYVE HAKE ETKK AIKY QSKA RRKL |
| Gene ID: | 2054 |
| Uniprot: | P32856 |
| Cellular Location: | Membrane, Single-pass type IV membrane protein |
| Calculated MW: | 32kDa/33kDa |
| Observed MW: | 36kDa |
| Synonyms: | STX2, EPIM, EPM, STX2A, STX2B, STX2C |
| Background: | The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| UniProt Protein Function: | STX2: Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. Belongs to the syntaxin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Vesicle; Membrane protein, integral Chromosomal Location of Human Ortholog: 12q24.33 Cellular Component: basolateral plasma membrane; extracellular space; integral to membrane; intracellular membrane-bound organelle; lamellipodium; plasma membrane; SNARE complex; synaptic vesicle Molecular Function:calcium-dependent protein binding; protein binding; protein dimerization activity; SNAP receptor activity; SNARE binding Biological Process: acrosome reaction; ectoderm development; intracellular protein transport; organ morphogenesis; protein oligomerization; regulation of blood coagulation; response to hydroperoxide; signal transduction; synaptic vesicle fusion to presynaptic membrane; vesicle docking |
| NCBI Summary: | The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P32856 |
| NCBI GenInfo Identifier: | 292495060 |
| NCBI Gene ID: | 2054 |
| NCBI Accession: | P32856.3 |
| UniProt Secondary Accession: | P32856,Q86VW8, |
| UniProt Related Accession: | P32856 |
| Molecular Weight: | 32,425 Da |
| NCBI Full Name: | Syntaxin-2 |
| NCBI Synonym Full Names: | syntaxin 2 |
| NCBI Official Symbol: | STX2 |
| NCBI Official Synonym Symbols: | EPM; EPIM; STX2A; STX2B; STX2C |
| NCBI Protein Information: | syntaxin-2 |
| UniProt Protein Name: | Syntaxin-2 |
| UniProt Synonym Protein Names: | Epimorphin |
| Protein Family: | Syntaxin |
| UniProt Gene Name: | STX2 |
| UniProt Entry Name: | STX2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using STX2 antibody (CAB10444) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunofluorescence analysis of NIH/3T3 cells using STX2 antibody (CAB10444) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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