Anti-STOM Antibody (CAB6372)
- SKU:
- CAB6372
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-STOM Antibody |
| Antibody SKU: | CAB6372 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 55-288 of human STOM (NP_004090.4). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:20 - 1:50 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse liver, Mouse spleen, Mouse heart, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 55-288 of human STOM (NP_004090.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KIIK EYER AIIF RLGR ILQG GAKG PGLF FILP CTDS FIKV DMRT ISFD IPPQ EILT KDSV TISV DGVV YYRV QNAT LAVA NITN ADSA TRLL AQTT LRNV LGTK NLSQ ILSD REEI AHNM QSTL DDAT DAWG IKVE RVEI KDVK LPVQ LQRA MAAE AEAS REAR AKVI AAEG EMNA SRAL KEAS MVIT ESPA ALQL RYLQ TLTT IAAE KNST IVFP LPID MLQG IIGA KHSH LG |
| Gene ID: | 2040 |
| Uniprot: | P27105 |
| Cellular Location: | Cell membrane, Cytoplasmic side, Cytoplasmic vesicle, Lipid-anchor, Melanosome, Peripheral membrane protein |
| Calculated MW: | 13kDa/31kDa |
| Observed MW: | 32kDa |
| Synonyms: | STOM, BND7, EPB7, EPB72, stomatin |
| Background: | This gene encodes a member of a highly conserved family of integral membrane proteins. The encoded protein localizes to the cell membrane of red blood cells and other cell types, where it may regulate ion channels and transporters. Loss of localization of the encoded protein is associated with hereditary stomatocytosis, a form of hemolytic anemia. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | stomatin: Thought to regulate cation conductance. May regulate ASIC2 and ASIC3 gating. Belongs to the band 7/mec-2 family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold; Membrane protein, integral Chromosomal Location of Human Ortholog: 9q34.1 Cellular Component: cytoplasm; cytoskeleton; endoplasmic reticulum; extracellular space; integral to plasma membrane; lipid raft; membrane; mitochondrion; vesicle Molecular Function:protein binding Biological Process: positive regulation of defense response to virus by host; protein homooligomerization Disease: Overhydrated Hereditary Stomatocytosis |
| NCBI Summary: | This gene encodes a member of a highly conserved family of integral membrane proteins. The encoded protein localizes to the cell membrane of red blood cells and other cell types, where it may regulate ion channels and transporters. Loss of localization of the encoded protein is associated with hereditary stomatocytosis, a form of hemolytic anemia. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] |
| UniProt Code: | P27105 |
| NCBI GenInfo Identifier: | 114823 |
| NCBI Gene ID: | 2040 |
| NCBI Accession: | P27105.3 |
| UniProt Secondary Accession: | P27105,Q14087, Q15609, Q5VX96, Q96FK4, B1AM77, |
| UniProt Related Accession: | P27105 |
| Molecular Weight: | 13,475 Da |
| NCBI Full Name: | Erythrocyte band 7 integral membrane protein |
| NCBI Synonym Full Names: | stomatin |
| NCBI Official Symbol: | STOM |
| NCBI Official Synonym Symbols: | BND7; EPB7; EPB72 |
| NCBI Protein Information: | erythrocyte band 7 integral membrane protein |
| UniProt Protein Name: | Erythrocyte band 7 integral membrane protein |
| UniProt Synonym Protein Names: | Protein 7.2b; Stomatin |
| Protein Family: | Stomatin |
| UniProt Gene Name: | STOM |
| UniProt Entry Name: | STOM_HUMAN |
 | Western blot analysis of extracts of various cell lines, using STOM antibody (CAB6372) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of HeLa cells using STOM antibody (CAB6372). Blue: DAPI for nuclear staining. |
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