Anti-STEAP4 Antibody (CAB17767)
- SKU:
- CAB17767
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| Antibody Name: | Anti-STEAP4 Antibody |
| Antibody SKU: | CAB17767 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human STEAP4 (NP_001192245). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Rat liver, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human STEAP4 (NP_001192245). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEKT CIDA LPLT MNSS EKQE TVCI FGTG DFGR SLGL KMLQ CGYS VVFG SRNP QKTT LLPS GAEV LSYS EAAK KSGI IIIA IHRE HYDF LTEL TEVL NGKI |
| Gene ID: | 79689 |
| Uniprot: | Q687X5 |
| Cellular Location: | |
| Calculated MW: | 31kDa/51kDa |
| Observed MW: | 52kDa |
 | Western blot - STEAP4 Polyclonal Antibody (CAB17767) |
| Synonyms: | STAMP2, SchLAH, TIARP, TNFAIP9, STEAP4 |
| Background: | The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011] |
| UniProt Protein Function: | STEAP4: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses. Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation. Belongs to the STEAP family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; EC 1.16.1.-; Oxidoreductase Chromosomal Location of Human Ortholog: 7q21.12 Cellular Component: Golgi membrane; integral to membrane; plasma membrane; endosome Molecular Function:metal ion binding; cupric reductase activity Biological Process: fat cell differentiation; iron ion homeostasis; copper ion import |
| NCBI Summary: | The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011] |
| UniProt Code: | Q687X5 |
| NCBI GenInfo Identifier: | 74748242 |
| NCBI Gene ID: | 79689 |
| NCBI Accession: | Q687X5.1 |
| UniProt Secondary Accession: | Q687X5,Q658Q9, Q687X4, Q8WWB0, Q9H5R1, |
| UniProt Related Accession: | Q687X5 |
| Molecular Weight: | 52kDa |
| NCBI Full Name: | Metalloreductase STEAP4 |
| NCBI Synonym Full Names: | STEAP family member 4 |
| NCBI Official Symbol: | STEAP4 |
| NCBI Official Synonym Symbols: | TIARP; STAMP2; TNFAIP9 |
| NCBI Protein Information: | metalloreductase STEAP4; six transmembrane prostate protein 2; sixTransMembrane protein of prostate 2; tumor necrosis factor, alpha-induced protein 9; six-transmembrane epithelial antigen of prostate 4; tumor necrosis-alpha-induced adipose-related protein |
| UniProt Protein Name: | Metalloreductase STEAP4 |
| UniProt Synonym Protein Names: | Six-transmembrane epithelial antigen of prostate 4; SixTransMembrane protein of prostate 2; Tumor necrosis factor, alpha-induced protein 9 |
| Protein Family: | Metalloreductase |
| UniProt Gene Name: | STEAP4 |
| UniProt Entry Name: | STEA4_HUMAN |
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