Anti-ST8SIA1 Antibody (CAB9648)
- SKU:
- CAB9648
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-ST8SIA1 Antibody |
| Antibody SKU: | CAB9648 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 49-270 of human ST8SIA1 (NP_003025.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | A-549, SGC-7901 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 49-270 of human ST8SIA1 (NP_003025.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YRLP NEKE IVQG VLQQ GTAW RRNQ TAAR AFRK QMED CCDP AHLF AMTK MNSP MGKS MWYD GEFL YSFT IDNS TYSL FPQA TPFQ LPLK KCAV VGNG GILK KSGC GRQI DEAN FVMR CNLP PLSS EYTK DVGS KSQL VTAN PSII RQRF QNLL WSRK TFVD NMKI YNHS YIYM PAFS MKTG TEPS LRVY YTLS DVGA NQTV LFAN PNFL RSIG KFWK SRGI HA |
| Gene ID: | 6489 |
| Uniprot: | Q92185 |
| Cellular Location: | Golgi apparatus membrane, Single-pass type II membrane protein |
| Calculated MW: | 15kDa/40kDa |
| Observed MW: | 40kDa |
| Synonyms: | ST8SIA1, GD3S, SIAT8, SIAT8-A, SIAT8A, ST8SiaI |
| Background: | Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29. Alternatively spliced transcript variants have been found for this gene. |
| UniProt Protein Function: | ST8SIA1: Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid. Belongs to the glycosyltransferase 29 family. |
| UniProt Protein Details: | Protein type:Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; Glycan Metabolism - glycosphingolipid biosynthesis - globo series; EC 2.4.99.8; Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series; Membrane protein, integral; Transferase Chromosomal Location of Human Ortholog: 12p12.1-p11.2 Cellular Component: Golgi membrane; integral to membrane; integral to Golgi membrane Molecular Function:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity; sialyltransferase activity Biological Process: glycosphingolipid biosynthetic process; cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; carbohydrate metabolic process; positive regulation of cell proliferation; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification |
| NCBI Summary: | Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92185 |
| NCBI GenInfo Identifier: | 2494829 |
| NCBI Gene ID: | 6489 |
| NCBI Accession: | Q92185.1 |
| UniProt Secondary Accession: | Q92185,Q17RL0, Q6PZN5, Q93064, A8K4H6, |
| UniProt Related Accession: | Q92185 |
| Molecular Weight: | 15,504 Da |
| NCBI Full Name: | Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase |
| NCBI Synonym Full Names: | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 |
| NCBI Official Symbol: | ST8SIA1 |
| NCBI Official Synonym Symbols: | GD3S; SIAT8; SIAT8A; SIAT8-A; ST8SiaI |
| NCBI Protein Information: | alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ganglioside GD3 synthase; ganglioside GT3 synthase; sialytransferase St8Sia I; sialyltransferase St8Sia I; alpha-2,8-sialyltransferase 8A; disialoganglioside (GD3) synthase; ganglioside-specific alpha-2,8-polysialyltransferase; sialyltransferase 8 (alpha-N-acetylneuraminate: alpha-2,8-sialytransferase, GD3 synthase) A; sialyltransferase 8A (alpha-N-acetylneuraminate: alpha-2,8-sialyltransferase, GD3 synthase) |
| UniProt Protein Name: | Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase |
| UniProt Synonym Protein Names: | Alpha-2,8-sialyltransferase 8A; Ganglioside GD3 synthase; Ganglioside GT3 synthase; Sialyltransferase 8A; SIAT8-A; Sialyltransferase St8Sia I; ST8SiaI |
| Protein Family: | Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase |
| UniProt Gene Name: | ST8SIA1 |
| UniProt Entry Name: | SIA8A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ST8SIA1 antibody (CAB9648) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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