Anti-ST6GALNAC4 Antibody (CAB12880)
- SKU:
- CAB12880
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-ST6GALNAC4 Antibody |
| Antibody SKU: | CAB12880 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-210 of human ST6GALNAC4 (NP_778204.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-210 of human ST6GALNAC4 (NP_778204.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TLRV VSHT SVPL LLRN YSHY FQKA RDTL YMVW GQGR HMDR VLGG RTYR TLLQ LTRM YPGL QVYT FTER MMAY CDQI FQDE TGKN RRQS GSF |
| Gene ID: | 27090 |
| Uniprot: | Q9H4F1 |
| Cellular Location: | Golgi apparatus membrane, Single-pass type II membrane protein |
| Calculated MW: | 34kDa |
| Observed MW: | 34kDa |
| Synonyms: | ST6GALNAC4, IV, SIAT3-C, SIAT3C, SIAT7-D, SIAT7D, ST6GALNACIV, ST6GalNAc |
| Background: | The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2, 3-Gal-beta-1, 3-GalNAc. In addition, it is involved in the synthesis of ganglioside GD1A from GM1B. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | ST6GALNAC4: Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. Prefers glycoproteins to glycolipids. Belongs to the glycosyltransferase 29 family. |
| UniProt Protein Details: | Protein type:Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series; Membrane protein, integral; EC 2.4.99.7; Transferase Chromosomal Location of Human Ortholog: 9q34 Cellular Component: Golgi membrane Molecular Function:(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity; sialyltransferase activity Biological Process: ganglioside biosynthetic process; glycolipid metabolic process; O-glycan processing; oligosaccharide metabolic process; protein amino acid N-linked glycosylation via asparagine |
| NCBI Summary: | The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. In addition, it is involved in the synthesis of ganglioside GD1A from GM1B. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H4F1 |
| NCBI GenInfo Identifier: | 21759443 |
| NCBI Gene ID: | 27090 |
| NCBI Accession: | Q9H4F1.2 |
| UniProt Secondary Accession: | Q9H4F1,Q5T9D0, Q9NWU6, Q9UKU1, Q9ULB9, Q9Y3G3, Q9Y3G4 |
| UniProt Related Accession: | Q9H4F1 |
| Molecular Weight: | 34,201 Da |
| NCBI Full Name: | Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase |
| NCBI Synonym Full Names: | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 |
| NCBI Official Symbol: | ST6GALNAC4 |
| NCBI Official Synonym Symbols: | IV; SIAT3C; SIAT7D; SIAT3-C; SIAT7-D; ST6GalNAc; ST6GALNACIV |
| NCBI Protein Information: | alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase |
| UniProt Protein Name: | Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase |
| UniProt Synonym Protein Names: | NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase; ST6GalNAc IV; ST6GalNAcIV; Sialyltransferase 3C; SIAT3-C; Sialyltransferase 7D; SIAT7-D |
| Protein Family: | Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase |
| UniProt Gene Name: | ST6GALNAC4 |
| UniProt Entry Name: | SIA7D_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ST6GALNAC4 antibody (CAB12880) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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