Anti-SSTR1 Antibody (CAB3134)
- SKU:
- CAB3134
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-SSTR1 Antibody |
| Antibody SKU: | CAB3134 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human SSTR1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse liver, Mouse brain, Mouse heart, Mouse bone marrow |
| Immunogen: | A synthetic peptide of human SSTR1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6751 |
| Uniprot: | P30872 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 42kDa |
| Observed MW: | 47kDa |
| Synonyms: | SSTR1, SRIF-2, SS-1-R, SS1-R, SS1R |
| Background: | Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. |
| UniProt Protein Function: | SSTR1: Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins. Belongs to the G-protein coupled receptor 1 family. Interacts with SKB1. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; GPCR, family 1; Cell cycle regulation; Receptor, GPCR; Membrane protein, integral Chromosomal Location of Human Ortholog: 14q13 Cellular Component: neuron projection; integral to plasma membrane; cytoplasm; plasma membrane Molecular Function:neuropeptide binding; somatostatin receptor activity Biological Process: response to starvation; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of cell proliferation; synaptic transmission; cell surface receptor linked signal transduction; cell-cell signaling; glutamate signaling pathway; neuropeptide signaling pathway; digestion; forebrain development; cerebellum development; spermatogenesis; response to nutrient |
| NCBI Summary: | Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012] |
| UniProt Code: | P30872 |
| NCBI GenInfo Identifier: | 401124 |
| NCBI Gene ID: | 6751 |
| NCBI Accession: | P30872.1 |
| UniProt Related Accession: | P30872 |
| Molecular Weight: | Calculated MW: 42kDaObserved MW: 47kDa |
| NCBI Full Name: | Somatostatin receptor type 1 |
| NCBI Synonym Full Names: | somatostatin receptor 1 |
| NCBI Official Symbol: | SSTR1 |
| NCBI Official Synonym Symbols: | SS1R; SS1-R; SRIF-2; SS-1-R |
| NCBI Protein Information: | somatostatin receptor type 1 |
| UniProt Protein Name: | Somatostatin receptor type 1 |
| UniProt Synonym Protein Names: | SRIF-2 |
| Protein Family: | Somatostatin receptor |
| UniProt Gene Name: | SSTR1 |
| UniProt Entry Name: | SSR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SSTR1 antibody (CAB3134) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). |
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