Anti-SRPX2 Antibody (CAB15434)
- SKU:
- CAB15434
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Frequently bought together:
Description
| Antibody Name: | Anti-SRPX2 Antibody |
| Antibody SKU: | CAB15434 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 166-465 of human SRPX2 (NP_055282.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 166-465 of human SRPX2 (NP_055282.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DGRW SGGE PVCV DIDP PKIR CPHS REKM AEPE KLTA RVYW DPPL VKDS ADGT ITRV TLRG PEPG SHFP EGEH VIRY TAYD RAYN RASC KFIV KVQV RRCP TLKP PQHG YLTC TSAG DNYG ATCE YHCD GGYD RQGT PSRV CQSS RQWS GSPP ICAP MKIN VNVN SAAG LLDQ FYEK QRLL IISA PDPS NRYY KMQI SMLQ QSTC GLDL RHVT IIEL VGQP PQEV GRIR EQQL SANI IEEL RQFQ RLTR SYFN MVLI DKQG IDRD RYME PVTP EEIF TFID DYLL SNQE LTQR REQR DICE |
| Gene ID: | 27286 |
| Uniprot: | O60687 |
| Cellular Location: | Cell junction, Cell surface, Cytoplasm, Secreted, synapse |
| Calculated MW: | 52kDa |
| Observed MW: | 53kDa |
| Synonyms: | SRPX2, BPP, CBPS, PMGX, RESDX, SRPUL |
| Background: | This gene encodes a secreted protein that contains three sushi repeat motifs. The encoded protein may play a role in the development of speech and language centers in the brain. This protein may also be involved in angiogenesis. Mutations in this gene are the cause of bilateral perisylvian polymicrogyria, rolandic epilepsy, speech dyspraxia and mental retardation. |
| UniProt Protein Function: | SRPX2: Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion in cancer cells. Increases the phosphorylation levels of FAK. May have a role in the perisylvian region, critical for language and cognitive development. Defects in SRPX2 are a cause of bilateral perisylvian polymicrogyria (BPP). BPP is the most common form of polymicrogyria, a malformation of the cortex, in which the brain surface is irregular and the normal gyral pattern replaced by multiple small, partly fused, gyri separated by shallow sulci. BPP results in mild mental retardation, epilepsy and pseudobulbar palsy, causing difficulties with expressive speech and feeding. Defects in SRPX2 are a cause of rolandic epilepsy with speech dyspraxia and mental retardation X-linked (RESDX). A condition characterized by the association of rolandic seizures with oral and speech dyspraxia, and mental retardation. Rolandic occur during a period of significant brain maturation. During this time, dysfunction of neural network activities such as focal discharges may be associated with specific developmental disabilities resulting in specific cognitive impairments of language, visuo-spatial abilities or attention. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: Xq22.1 Cellular Component: extracellular space; cell surface; cytoplasm; excitatory synapse; cell junction Molecular Function:identical protein binding; protein binding; receptor binding Biological Process: positive regulation of synaptogenesis; cell-cell adhesion; regulation of phosphorylation; cell motility involved in cell locomotion; angiogenesis Disease: Rolandic Epilepsy, Mental Retardation, And Speech Dyspraxia, X-linked |
| NCBI Summary: | This gene encodes a secreted protein that contains three sushi repeat motifs. The encoded protein may play a role in the development of speech and language centers in the brain. This protein may also be involved in angiogenesis. Mutations in this gene are the cause of bilateral perisylvian polymicrogyria, rolandic epilepsy, speech dyspraxia and cognitive disability. [provided by RefSeq, May 2010] |
| UniProt Code: | O60687 |
| NCBI GenInfo Identifier: | 7657619 |
| NCBI Gene ID: | 27286 |
| NCBI Accession: | NP_055282 |
| UniProt Related Accession: | O60687 |
| Molecular Weight: | 52kDa |
| NCBI Full Name: | sushi repeat-containing protein SRPX2 |
| NCBI Synonym Full Names: | sushi repeat containing protein X-linked 2 |
| NCBI Official Symbol: | SRPX2 |
| NCBI Official Synonym Symbols: | BPP; CBPS; PMGX; RESDX; SRPUL |
| NCBI Protein Information: | sushi repeat-containing protein SRPX2 |
| UniProt Protein Name: | Sushi repeat-containing protein SRPX2 |
| UniProt Synonym Protein Names: | Sushi-repeat protein upregulated in leukemia |
| Protein Family: | Sushi repeat-containing protein |
| UniProt Gene Name: | SRPX2 |
| UniProt Entry Name: | SRPX2_HUMAN |
 | Western blot analysis of extracts of mouse brain, using SRPX2 antibody (CAB15434) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s. |
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