Anti-SRGAP2 Antibody (CAB19512)
- SKU:
- CAB19512
- Product type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- SRGAP2
- ARHGAP34
- FNBP2
- SRGAP2A
- SRGAP3
Frequently bought together:
Description
| Product Name: | SRGAP2 Rabbit pAb |
| Product Code: | CAB19512 |
| Size: | 50uL, 100uL |
| Synonyms: | SRGAP2, ARHGAP34, FNBP2, SRGAP2A, SRGAP3 |
| Applications: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic Peptide of human SRGAP2 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:1000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse brain |
| Immunogen: | A synthetic Peptide of human SRGAP2 |
| Purification Method: | Affinity purification |
| Storage: | Store at 4°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 23380 |
| Uniprot: | O75044 |
| Cellular Location: | Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Nucleus, dendritic spine, lamellipodium, phagosome, postsynaptic cell membrane, postsynaptic density, synapse |
| Calculated MW: | 120kDa |
| Observed MW: | 140KDa |
| UniProt Protein Function: | SRGAP2: RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia. A chromosomal aberration disrupting SRGAP2 has been found in a patient with early infantile epileptic encephalopathy. Balanced translocation t(1;9)(q32;q13). |
| UniProt Protein Details: | Protein type:GAPs; Motility/polarity/chemotaxis; Mitochondrial; GAPs, Rac/Rho Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: cytoplasm; cytosol; lamellipodium; phagocytic vesicle; plasma membrane; postsynaptic density; postsynaptic membrane Molecular Function:GTPase activator activity; protein binding; protein homodimerization activity; Rac GTPase binding Biological Process: actin filament severing; cell proliferation; extension of a leading process involved in cell locomotion in cerebral cortex radial glia guided migration; filopodium formation; neurite morphogenesis; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction |
| NCBI Summary: | This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014] |
| UniProt Code: | O75044 |
| NCBI GenInfo Identifier: | 48427907 |
| NCBI Gene ID: | 23380 |
| NCBI Accession: | O75044.2 |
| UniProt Related Accession: | O75044 |
| Molecular Weight: | 120,881 Da |
| NCBI Full Name: | SLIT-ROBO Rho GTPase-activating protein 2 |
| NCBI Synonym Full Names: | SLIT-ROBO Rho GTPase activating protein 2 |
| NCBI Official Symbol: | SRGAP2 |
| NCBI Official Synonym Symbols: | FNBP2; SRGAP3; SRGAP2A; ARHGAP34 |
| NCBI Protein Information: | SLIT-ROBO Rho GTPase-activating protein 2 |
| UniProt Protein Name: | SLIT-ROBO Rho GTPase-activating protein 2 |
| UniProt Synonym Protein Names: | Formin-binding protein 2; Rho GTPase-activating protein 34 |
| Protein Family: | SLIT-ROBO Rho GTPase-activating protein |
| UniProt Gene Name: | SRGAP2 |
| UniProt Entry Name: | SRGP2_HUMAN |
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