Anti-SREBP2 Antibody (CAB13049)

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SKU:
CAB13049
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
Frequently bought together:

Description

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Antibody Name:Anti-SREBP2 Antibody
Antibody SKU:CAB13049
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human SREBF2 (NP_004590.2).
Application:WB IHC IF
Recommended Dilution:WB 1:1000 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, LO2, 293T, HeLa, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human SREBF2 (NP_004590.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDDS GELG GLET METL TELG DELT LGDI DEML QFVS NQVG EFPD LFSE QLCS SFPG SGGS GSSS GSSG SSSS SSNG RGSS SGAV DPSV QRSF TQVT LPSF SPSA ASPQ APTL QVKV SPTS VPTT PRAT PILQ PRPQ PQPQ PQTQ LQQQ TVMI TPTF STTP QTRI IQQP LIYQ NAAT SFQV LQPQ VQSL VTSS QVQP VTIQ QQVQ TVQA QRVL TQTA NGTL
Gene ID:6721
Uniprot:Q12772
Cellular Location:COPII-coated vesicle membrane, Cytoplasmic vesicle, Endoplasmic reticulum membrane, Golgi apparatus membrane, Multi-pass membrane protein, Multi-pass membrane protein, Nucleus
Calculated MW:73kDa/123kDa
Observed MW:60kDa
Synonyms:SREBF2, SREBP-2, SREBP2, bHLHd2
Background:This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants.
UniProt Protein Function:Transcriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.
UniProt Code:Q12772
NCBI GenInfo Identifier:148235634
NCBI Gene ID:100037309
NCBI Accession:NP_001082935.1
UniProt Related Accession:A3KNA7
Molecular Weight:120321
NCBI Full Name:sterol regulatory element-binding protein 2
NCBI Synonym Full Names:sterol regulatory element binding transcription factor 2
NCBI Official Symbol:srebf2  
NCBI Official Synonym Symbols:zgc:158371  
NCBI Protein Information:sterol regulatory element-binding protein 2
UniProt Protein Name:Sterol regulatory element-binding protein 2
UniProt Synonym Protein Names:Sterol regulatory element-binding transcription factor 2
Protein Family:Sterol regulatory element-binding protein
UniProt Gene Name:srebf2  
UniProt Entry Name:SRBP2_DANRE
Anti-SREBP2 Antibody (CAB13049)Western blot analysis of extracts of various cell lines, using SREBP2 antibody (CAB13049) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Anti-SREBP2 Antibody (CAB13049)Immunohistochemistry of paraffin-embedded Human gastric cancer using SREBP2 antibody (CAB13049) at dilution of 1:100 (40x lens).
Anti-SREBP2 Antibody (CAB13049)Immunofluorescence analysis of L929 cells using SREBP2 Rabbit pAb (CAB13049) at dilution of 1:100. Blue: DAPI for nuclear staining.
Anti-SREBP2 Antibody (CAB13049)Immunofluorescence analysis of U2OS cells using SREBP2 Rabbit pAb (CAB13049) at dilution of 1:100. Blue: DAPI for nuclear staining.

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