Anti-SRA1 Antibody (CAB16296)
- SKU:
- CAB16296
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-SRA1 Antibody |
| Antibody SKU: | CAB16296 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SRA1 (NP_001030312.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-431, Mouse testis, Rat liver |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SRA1 (NP_001030312.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTRC PAGQ AEVE MAEL YVKP GNKE RGWN DPPQ FSYG LQTQ AGGP RRSL LTKR VAAP QDGS PRVP ASET SPGP PPMG PPPP SSKA PRSP PVGS GPAS GVEP |
| Gene ID: | 10011 |
| Uniprot: | Q9HD15 |
| Cellular Location: | |
| Calculated MW: | 25kDa |
| Observed MW: | 26kDa, 37kDa |
| Synonyms: | SRA1, SRA, SRAP, STRAA1, pp7684 |
| Background: | Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. |
| UniProt Protein Function: | SRA1: Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand- dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis. Belongs to the SRA1 family. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 5q31.3 Cellular Component: nucleoplasm; microtubule cytoskeleton; intercellular bridge; cytoplasm; plasma membrane; nucleus; ribonucleoprotein complex Molecular Function:protein binding; ligand-dependent nuclear receptor transcription coactivator activity; transcription coactivator activity Biological Process: regulation of apoptosis; cell proliferation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; apoptosis; cell differentiation |
| NCBI Summary: | Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012] |
| UniProt Code: | Q9HD15 |
| NCBI GenInfo Identifier: | 74718904 |
| NCBI Gene ID: | 10011 |
| NCBI Accession: | Q9HD15.1 |
| UniProt Secondary Accession: | Q9HD15,Q6NVU9, Q8IXM1, Q9HD13, Q9HD14, |
| UniProt Related Accession: | Q9HD15 |
| Molecular Weight: | 25,673 Da |
| NCBI Full Name: | Steroid receptor RNA activator 1 |
| NCBI Synonym Full Names: | steroid receptor RNA activator 1 |
| NCBI Official Symbol: | SRA1 |
| NCBI Official Synonym Symbols: | SRA; SRAP; STRAA1; pp7684 |
| NCBI Protein Information: | steroid receptor RNA activator 1; SRA1; steroid receptor coactivator; steroid receptor RNA activator protein; steroid receptor RNA activator 1 (complexes with NCOA1) |
| UniProt Protein Name: | Steroid receptor RNA activator 1 |
| UniProt Synonym Protein Names: | Steroid receptor RNA activator protein; SRAP |
| Protein Family: | Steroid receptor RNA activator |
| UniProt Gene Name: | SRA1 |
| UniProt Entry Name: | SRA1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SRA1 antibody (CAB16296) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min. |
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